Cross-species cluster co-conservation: a new method for generating protein interaction networks

Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC ha...

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Autores principales: Karimpour-Fard, Anis, Detweiler, Corrella S, Erickson, Kimberly D, Hunter, Lawrence, Gill, Ryan T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375023/
https://www.ncbi.nlm.nih.gov/pubmed/17803817
http://dx.doi.org/10.1186/gb-2007-8-9-r185
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author Karimpour-Fard, Anis
Detweiler, Corrella S
Erickson, Kimberly D
Hunter, Lawrence
Gill, Ryan T
author_facet Karimpour-Fard, Anis
Detweiler, Corrella S
Erickson, Kimberly D
Hunter, Lawrence
Gill, Ryan T
author_sort Karimpour-Fard, Anis
collection PubMed
description Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation.
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spelling pubmed-23750232008-05-10 Cross-species cluster co-conservation: a new method for generating protein interaction networks Karimpour-Fard, Anis Detweiler, Corrella S Erickson, Kimberly D Hunter, Lawrence Gill, Ryan T Genome Biol Method Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation. BioMed Central 2007 2007-09-05 /pmc/articles/PMC2375023/ /pubmed/17803817 http://dx.doi.org/10.1186/gb-2007-8-9-r185 Text en Copyright © 2007 Karimpour-Fard et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Karimpour-Fard, Anis
Detweiler, Corrella S
Erickson, Kimberly D
Hunter, Lawrence
Gill, Ryan T
Cross-species cluster co-conservation: a new method for generating protein interaction networks
title Cross-species cluster co-conservation: a new method for generating protein interaction networks
title_full Cross-species cluster co-conservation: a new method for generating protein interaction networks
title_fullStr Cross-species cluster co-conservation: a new method for generating protein interaction networks
title_full_unstemmed Cross-species cluster co-conservation: a new method for generating protein interaction networks
title_short Cross-species cluster co-conservation: a new method for generating protein interaction networks
title_sort cross-species cluster co-conservation: a new method for generating protein interaction networks
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375023/
https://www.ncbi.nlm.nih.gov/pubmed/17803817
http://dx.doi.org/10.1186/gb-2007-8-9-r185
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AT hunterlawrence crossspeciesclustercoconservationanewmethodforgeneratingproteininteractionnetworks
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