Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated level, transactivates the miRNA 17-5p-92 cluster, which inhibits p21 and BIM translation by interaction with their mRNA 3′ UTRs. Overexpression of miRNA 17-5p-92 cluster in MYCN-not-...

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Detalles Bibliográficos
Autores principales: Fontana, Laura, Fiori, Micol E., Albini, Sonia, Cifaldi, Loredana, Giovinazzi, Serena, Forloni, Matteo, Boldrini, Renata, Donfrancesco, Alberto, Federici, Valentina, Giacomini, Patrizio, Peschle, Cesare, Fruci, Doriana
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375057/
https://www.ncbi.nlm.nih.gov/pubmed/18493594
http://dx.doi.org/10.1371/journal.pone.0002236

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