CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation

Physical interaction between CDKN2A/p16 and CDK4 proteins regulates the cell cycle progression through the G1 phase and dysfunction of these proteins by gene mutation is implicated in genetic predisposition to melanoma. We analysed 15 Italian melanoma families for germ line mutations in the coding r...

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Detalles Bibliográficos
Autores principales: Torre, G Della, Pasini, B, Frigerio, S, Donghi, R, Rovini, D, Delia, D, Peters, G, Huot, T J G, Bianchi-Scarra, G, Lantieri, F, Rodolfo, M, Parmiani, G, Pierotti, M A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375081/
https://www.ncbi.nlm.nih.gov/pubmed/11556834
http://dx.doi.org/10.1054/bjoc.2001.1991

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