Frequent somatic loss of BRCA1 in breast tumours from BRCA2 germ-line mutation carriers and vice versa

Breast cancer susceptibility genes BRCA1 and BRCA2 are tumour suppressor genes the alleles of which have to be inactivated before tumour development occurs. Hereditary breast cancers linked to germ-line mutations of BRCA1 and BRCA2 genes almost invariably show allelic imbalance (AI) at the respectiv...

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Detalles Bibliográficos
Autores principales: Staff, S, Isola, J J, Johannsson, O, Borg, Å, Tanner, M M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375151/
https://www.ncbi.nlm.nih.gov/pubmed/11710835
http://dx.doi.org/10.1054/bjoc.2001.2062

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