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A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

The indolequinone EO9 demonstrated good preclinical activity but failed to show clinical efficacy against a range of tumours following intravenous drug administration. A significant factor in EO9's failure in the clinic has been attributed to its rapid pharmacokinetic elimination resulting in p...

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Detalles Bibliográficos
Autores principales:	Choudry, G A, Stewart, P A Hamilton, Double, J A, Krul, M R L, Naylor, B, Flannigan, G M, Shah, T K, Brown, J E, Phillips, R M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375160/ https://www.ncbi.nlm.nih.gov/pubmed/11710826 http://dx.doi.org/10.1054/bjoc.2001.2056

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