Screening for oesophageal neoplasia in patients with head and neck cancer

Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cance...

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Autores principales: Scherübl, H, Lampe, B von, Faiss, S, Däubler, P, Bohlmann, P, Plath, T, Foss, H-D, Scherer, H, Strunz, A, Hoffmeister, B, Stein, H, Zeitz, M, Riecken, E-O
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375180/
https://www.ncbi.nlm.nih.gov/pubmed/11870513
http://dx.doi.org/10.1038/sj.bjc.6600018
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author Scherübl, H
Lampe, B von
Faiss, S
Däubler, P
Bohlmann, P
Plath, T
Foss, H-D
Scherer, H
Strunz, A
Hoffmeister, B
Stein, H
Zeitz, M
Riecken, E-O
author_facet Scherübl, H
Lampe, B von
Faiss, S
Däubler, P
Bohlmann, P
Plath, T
Foss, H-D
Scherer, H
Strunz, A
Hoffmeister, B
Stein, H
Zeitz, M
Riecken, E-O
author_sort Scherübl, H
collection PubMed
description Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low- or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group. British Journal of Cancer (2002) 86, 239–243. DOI: 10.1038/sj/bjc/6600018 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-23751802009-09-10 Screening for oesophageal neoplasia in patients with head and neck cancer Scherübl, H Lampe, B von Faiss, S Däubler, P Bohlmann, P Plath, T Foss, H-D Scherer, H Strunz, A Hoffmeister, B Stein, H Zeitz, M Riecken, E-O Br J Cancer Molecular and Cellular Pathology Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low- or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group. British Journal of Cancer (2002) 86, 239–243. DOI: 10.1038/sj/bjc/6600018 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-01-21 /pmc/articles/PMC2375180/ /pubmed/11870513 http://dx.doi.org/10.1038/sj.bjc.6600018 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Scherübl, H
Lampe, B von
Faiss, S
Däubler, P
Bohlmann, P
Plath, T
Foss, H-D
Scherer, H
Strunz, A
Hoffmeister, B
Stein, H
Zeitz, M
Riecken, E-O
Screening for oesophageal neoplasia in patients with head and neck cancer
title Screening for oesophageal neoplasia in patients with head and neck cancer
title_full Screening for oesophageal neoplasia in patients with head and neck cancer
title_fullStr Screening for oesophageal neoplasia in patients with head and neck cancer
title_full_unstemmed Screening for oesophageal neoplasia in patients with head and neck cancer
title_short Screening for oesophageal neoplasia in patients with head and neck cancer
title_sort screening for oesophageal neoplasia in patients with head and neck cancer
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375180/
https://www.ncbi.nlm.nih.gov/pubmed/11870513
http://dx.doi.org/10.1038/sj.bjc.6600018
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