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Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin

Intensification of intra-arterial chemotherapy with high-dose cisplatin and concomitant reduction of toxicity under the conditions of the head and neck was aimed at by combination of antineoplastic activity and embolizing effect in the same pharmacon. A cisplatin suspension in normal saline (5 mg in...

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Autores principales: Kovács, A F, Obitz, P, Wagner, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375182/
https://www.ncbi.nlm.nih.gov/pubmed/11870505
http://dx.doi.org/10.1038/sj.bjc.6600042
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author Kovács, A F
Obitz, P
Wagner, M
author_facet Kovács, A F
Obitz, P
Wagner, M
author_sort Kovács, A F
collection PubMed
description Intensification of intra-arterial chemotherapy with high-dose cisplatin and concomitant reduction of toxicity under the conditions of the head and neck was aimed at by combination of antineoplastic activity and embolizing effect in the same pharmacon. A cisplatin suspension in normal saline (5 mg in 1 ml) with precipitation of microembolizing cisplatin crystals was prepared. No additional pharmacons. Cisplatin dosage was 150 mg m(−2), maximum absolute dose 300 mg, maximum amount of fluid 60 ml. Thirty patients (UICC-Classification of tumours: I/2 patients, II/6, III/2; IV/20) were treated in a neoadjuvant setting with superselective chemoembolization using the cisplatin suspension. A control group (n=30) with the same tumour and nodal staging was treated with a usual cisplatin solution (150 mg m(−2) dissolved in 500 ml saline). In both groups, parallel intravenous infusion of sodium thiosulphate (9 g m(−2)). Endpoints were toxicity and response. Continuation of treatment by surgery or radiation. Overall remission was 70% in the study group and 46.7% in the control group after one cycle respectively. Systemic side-effects were very low (grade I WHO) in both groups. Side-effects were found to be similar to post-embolization syndrome (swelling, mild to moderate pain, leucocytosis without fever) in the study group. Chemoembolization in the head and neck area can be carried out routinely using this method. British Journal of Cancer (2002) 86, 196–202. DOI: 10.1038/sj/bjc/6600042 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-23751822009-09-10 Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin Kovács, A F Obitz, P Wagner, M Br J Cancer Clinical Intensification of intra-arterial chemotherapy with high-dose cisplatin and concomitant reduction of toxicity under the conditions of the head and neck was aimed at by combination of antineoplastic activity and embolizing effect in the same pharmacon. A cisplatin suspension in normal saline (5 mg in 1 ml) with precipitation of microembolizing cisplatin crystals was prepared. No additional pharmacons. Cisplatin dosage was 150 mg m(−2), maximum absolute dose 300 mg, maximum amount of fluid 60 ml. Thirty patients (UICC-Classification of tumours: I/2 patients, II/6, III/2; IV/20) were treated in a neoadjuvant setting with superselective chemoembolization using the cisplatin suspension. A control group (n=30) with the same tumour and nodal staging was treated with a usual cisplatin solution (150 mg m(−2) dissolved in 500 ml saline). In both groups, parallel intravenous infusion of sodium thiosulphate (9 g m(−2)). Endpoints were toxicity and response. Continuation of treatment by surgery or radiation. Overall remission was 70% in the study group and 46.7% in the control group after one cycle respectively. Systemic side-effects were very low (grade I WHO) in both groups. Side-effects were found to be similar to post-embolization syndrome (swelling, mild to moderate pain, leucocytosis without fever) in the study group. Chemoembolization in the head and neck area can be carried out routinely using this method. British Journal of Cancer (2002) 86, 196–202. DOI: 10.1038/sj/bjc/6600042 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-01-21 /pmc/articles/PMC2375182/ /pubmed/11870505 http://dx.doi.org/10.1038/sj.bjc.6600042 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Kovács, A F
Obitz, P
Wagner, M
Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title_full Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title_fullStr Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title_full_unstemmed Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title_short Monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
title_sort monocomponent chemoembolization in oral and oropharyngeal cancer using an aqueous crystal suspension of cisplatin
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375182/
https://www.ncbi.nlm.nih.gov/pubmed/11870505
http://dx.doi.org/10.1038/sj.bjc.6600042
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