Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines

We have determined the methylation status of the CpG island of the oestrogen receptor α gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor α showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor α protein, hyp...

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Detalles Bibliográficos
Autores principales: O'Doherty, A M, Church, S W, Russell, S E H, Nelson, J, Hickey, I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375192/
https://www.ncbi.nlm.nih.gov/pubmed/11870520
http://dx.doi.org/10.1038/sj.bjc.6600028
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author O'Doherty, A M
Church, S W
Russell, S E H
Nelson, J
Hickey, I
author_facet O'Doherty, A M
Church, S W
Russell, S E H
Nelson, J
Hickey, I
author_sort O'Doherty, A M
collection PubMed
description We have determined the methylation status of the CpG island of the oestrogen receptor α gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor α showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor α protein, hypermethylation was observed at the NotI site of the CpG island. These results indicate that aberrant hypermethylation may be responsible for a significant proportion of epithelial ovarian tumours in which oestrogen receptor α expression is lost. British Journal of Cancer (2002) 86, 282–284. DOI: 10.1038/sj/bjc/6600028 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-23751922009-09-10 Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines O'Doherty, A M Church, S W Russell, S E H Nelson, J Hickey, I Br J Cancer Genetics and Genomics We have determined the methylation status of the CpG island of the oestrogen receptor α gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor α showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor α protein, hypermethylation was observed at the NotI site of the CpG island. These results indicate that aberrant hypermethylation may be responsible for a significant proportion of epithelial ovarian tumours in which oestrogen receptor α expression is lost. British Journal of Cancer (2002) 86, 282–284. DOI: 10.1038/sj/bjc/6600028 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-01-21 /pmc/articles/PMC2375192/ /pubmed/11870520 http://dx.doi.org/10.1038/sj.bjc.6600028 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
O'Doherty, A M
Church, S W
Russell, S E H
Nelson, J
Hickey, I
Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title_full Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title_fullStr Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title_full_unstemmed Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title_short Methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
title_sort methylation status of oestrogen receptor-α gene promoter sequences in human ovarian epithelial cell lines
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375192/
https://www.ncbi.nlm.nih.gov/pubmed/11870520
http://dx.doi.org/10.1038/sj.bjc.6600028
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