Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin

The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic ef...

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Autores principales: Meczes, E L, Pearson, A D J, Austin, C A, Tilby, M J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375204/
https://www.ncbi.nlm.nih.gov/pubmed/11875719
http://dx.doi.org/10.1038/sj.bjc.6600060
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author Meczes, E L
Pearson, A D J
Austin, C A
Tilby, M J
author_facet Meczes, E L
Pearson, A D J
Austin, C A
Tilby, M J
author_sort Meczes, E L
collection PubMed
description The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. British Journal of Cancer (2002) 86, 485–489. DOI: 10.1038/sj/bjc/6600060 www.bjcancer.com © 2002 The Cancer Research Campaign
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spelling pubmed-23752042009-09-10 Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin Meczes, E L Pearson, A D J Austin, C A Tilby, M J Br J Cancer Experimental Therapeutics The growth inhibitory effects of cisplatin and etoposide on neuroblastoma cell lines were investigated in several scheduled combinations. Results were analyzed using median effect and combination index analyses. In all schedules in which cisplatin was administered prior to etoposide a synergistic effect was observed. Conversely, an antagonistic effect was seen in all schedules where etoposide was administered before cisplatin. British Journal of Cancer (2002) 86, 485–489. DOI: 10.1038/sj/bjc/6600060 www.bjcancer.com © 2002 The Cancer Research Campaign Nature Publishing Group 2002-02-01 /pmc/articles/PMC2375204/ /pubmed/11875719 http://dx.doi.org/10.1038/sj.bjc.6600060 Text en Copyright © 2002 The Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Meczes, E L
Pearson, A D J
Austin, C A
Tilby, M J
Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title_full Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title_fullStr Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title_full_unstemmed Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title_short Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
title_sort schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375204/
https://www.ncbi.nlm.nih.gov/pubmed/11875719
http://dx.doi.org/10.1038/sj.bjc.6600060
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