Interferon-α resistance in renal carcinoma cells is associated with defective induction of signal transducer and activator of transcription 1 which can be restored by a supernatant of phorbol 12-myristate 13-acetate stimulated peripheral blood mononuclear cells

Therapy of selected human malignancies with interferon-α is widely accepted but often complicated by the emergence of interferon-α resistance. Interferon is a pleiotropic cytokine with antiproliferative, antitumour, antiviral and immunmodulatory effect; it signals through the Jak-STAT signal transdu...

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Detalles Bibliográficos
Autores principales: Brinckmann, A, Axer, S, Jakschies, D, Dallmann, I, Grosse, J, Patzelt, T, Bernier, T, Emmendoerffer, A, Atzpodien, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375211/
https://www.ncbi.nlm.nih.gov/pubmed/11875714
http://dx.doi.org/10.1038/sj.bjc.6600066

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