AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the pres...

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Detalles Bibliográficos
Autores principales: Rivera, E, Arrieta, O, Guevara, P, Duarte-Rojo, A, Sotelo, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375243/
https://www.ncbi.nlm.nih.gov/pubmed/11720480
http://dx.doi.org/10.1054/bjoc.2001.2102
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author Rivera, E
Arrieta, O
Guevara, P
Duarte-Rojo, A
Sotelo, J
author_facet Rivera, E
Arrieta, O
Guevara, P
Duarte-Rojo, A
Sotelo, J
author_sort Rivera, E
collection PubMed
description Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor. © 2001 Cancer Research Campaign  http://www.bjcancer.com
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spelling pubmed-23752432009-09-10 AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma Rivera, E Arrieta, O Guevara, P Duarte-Rojo, A Sotelo, J Br J Cancer Regular Article Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor. © 2001 Cancer Research Campaign  http://www.bjcancer.com Nature Publishing Group 2001-11 2001-09-01 /pmc/articles/PMC2375243/ /pubmed/11720480 http://dx.doi.org/10.1054/bjoc.2001.2102 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Rivera, E
Arrieta, O
Guevara, P
Duarte-Rojo, A
Sotelo, J
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title_full AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title_fullStr AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title_full_unstemmed AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title_short AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
title_sort at1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375243/
https://www.ncbi.nlm.nih.gov/pubmed/11720480
http://dx.doi.org/10.1054/bjoc.2001.2102
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