New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells

A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (BTS) have been designed and synthesized as candidate antineoplastic drugs. Several of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhib...

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Detalles Bibliográficos
Autores principales: Alonso, M M, Encío, I, Martínez-Merino, V, Gil, M, Migliaccio, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375244/
https://www.ncbi.nlm.nih.gov/pubmed/11720481
http://dx.doi.org/10.1054/bjoc.2001.2083
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author Alonso, M M
Encío, I
Martínez-Merino, V
Gil, M
Migliaccio, M
author_facet Alonso, M M
Encío, I
Martínez-Merino, V
Gil, M
Migliaccio, M
author_sort Alonso, M M
collection PubMed
description A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (BTS) have been designed and synthesized as candidate antineoplastic drugs. Several of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhibit a tumour cell-specific NADH oxidase activity present in the membrane of CCRF-CEM cells. © 2001 Cancer Research Campaign
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spelling pubmed-23752442009-09-10 New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells Alonso, M M Encío, I Martínez-Merino, V Gil, M Migliaccio, M Br J Cancer Short Communication A series of benzo(b)thiophenesulfonamide 1,1-dioxide derivatives (BTS) have been designed and synthesized as candidate antineoplastic drugs. Several of these compounds have shown in vitro cytotoxic activity on leukaemic CCRF-CEM cells. The cytotoxic BTS, but not the inactive ones, were able to inhibit a tumour cell-specific NADH oxidase activity present in the membrane of CCRF-CEM cells. © 2001 Cancer Research Campaign Nature Publishing Group 2001-11 2001-09-01 /pmc/articles/PMC2375244/ /pubmed/11720481 http://dx.doi.org/10.1054/bjoc.2001.2083 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Alonso, M M
Encío, I
Martínez-Merino, V
Gil, M
Migliaccio, M
New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title_full New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title_fullStr New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title_full_unstemmed New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title_short New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells
title_sort new cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a nadh oxidase located in plasma membranes of tumour cells
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375244/
https://www.ncbi.nlm.nih.gov/pubmed/11720481
http://dx.doi.org/10.1054/bjoc.2001.2083
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