Cargando…

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

Akt/PKB is a serine/threonine protein kinase that regulates cell cycle progression, apoptosis and growth factor mediated cell survival in association with tyrosine kinase receptors. The protein is a downstream effector of erbB-2 with implications in breast cancer progression and drug resistance in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pérez-Tenorio, G, Stål, O
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375266/ https://www.ncbi.nlm.nih.gov/pubmed/11870534 http://dx.doi.org/10.1038/sj.bjc.6600126

Ejemplares similares

Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells
por: Hövelmann, S, et al.
Publicado: (2004)

Inverse relationship between ER-β and SRC-1 predicts outcome in endocrine-resistant breast cancer
por: Myers, E, et al.
Publicado: (2004)

Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome
por: Faneyte, I F, et al.
Publicado: (2003)

Predicting aggressive outcome in T1N0M0 breast cancer
por: Kronqvist, P, et al.
Publicado: (2004)

NESP55, a novel chromogranin-like peptide, is expressed in endocrine tumours of the pancreas and adrenal medulla but not in ileal carcinoids
por: Jakobsen, A-M, et al.
Publicado: (2003)

Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
por: Brenner, B, et al.
Publicado: (2002)

Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes
por: Kippenberger, Stefan, et al.
Publicado: (2009)

Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
por: Schlieman, M G, et al.
Publicado: (2003)

Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
por: Coradini, D, et al.
Publicado: (2003)

Wild-type oestrogen receptor beta (ERβ1) mRNA and protein expression in Tamoxifen-treated post-menopausal breast cancers
por: O'Neill, P A, et al.
Publicado: (2004)

Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients
por: Stendahl, M, et al.
Publicado: (2004)

Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer
por: Goffin, J R, et al.
Publicado: (2003)

Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance
por: Luo, L-Y, et al.
Publicado: (2002)

Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
por: Weigelt, B, et al.
Publicado: (2003)

Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells
por: Jin, X, et al.
Publicado: (2004)

Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome
por: Span, P N, et al.
Publicado: (2003)

Prognostic importance of survivin in breast cancer
por: Kennedy, S M, et al.
Publicado: (2003)

Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905)
por: Dales, J P, et al.
Publicado: (2004)

Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
por: Tynninen, O, et al.
Publicado: (2002)

Overexpression of the Ets-1 transcription factor in human breast cancer
por: Buggy, Y, et al.
Publicado: (2004)

Elevated expression and altered processing of fibulin-1 protein in human breast cancer
por: Greene, L M, et al.
Publicado: (2003)

Expression of S100A4, E-cadherin, α- and β-catenin in breast cancer biopsies
por: Pedersen, K B, et al.
Publicado: (2002)

Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer
por: Zammit, C, et al.
Publicado: (2002)

Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer
por: Savinainen, K J, et al.
Publicado: (2004)

Allelic loss at 19q12 and Xq11–12 predict an adverse clinical outcome in patients with mucinous ovarian tumours of low malignant potential
por: Nakayama, K, et al.
Publicado: (2004)

Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence
por: Coradini, D, et al.
Publicado: (2002)

p53 as a potential predictive factor of response to chemotherapy: feasibility of p53 assessment using a functional test in yeast from trucut biopsies in breast cancer patients
por: Bonnefoi, H, et al.
Publicado: (2002)

The association of breast mitogens with mammographic densities
por: Boyd, N F, et al.
Publicado: (2002)

Kallikrein gene downregulation in breast cancer
por: Yousef, G M, et al.
Publicado: (2004)

Role of biological markers in the clinical outcome of colon cancer
por: Nanni, O, et al.
Publicado: (2002)

Expression of oestrogen receptor beta (ERβ1) protein in human breast cancer biopsies
por: Saunders, P T K, et al.
Publicado: (2002)

HER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review
por: Carlsson, J, et al.
Publicado: (2004)

Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer
por: Damera, A, et al.
Publicado: (2003)

The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells
por: Hoey, R P, et al.
Publicado: (2003)

Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma
por: Pazgal, I, et al.
Publicado: (2002)

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours
por: Zurita, A J, et al.
Publicado: (2003)

Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
por: Abd El-Rehim, D M, et al.
Publicado: (2004)

Protein and mRNA expression of uPAR and PAI-1 in myoepithelial cells of early breast cancer lesions and normal breast tissue
por: Hildenbrand, R, et al.
Publicado: (2004)

Increased risk of malignant progression in benign proliferating breast lesions defined by expression of heat shock protein 27
por: O'Neill, P A, et al.
Publicado: (2004)

Quantitative evaluation of metastases in axillary lymph nodes of breast cancer
por: Inokuchi, M, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_7k3utankkm1tku958p68fq3n10