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Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability

Human cancers with a high frequency microsatellite instability phenotype develop due to defects in DNA mismatch repair genes. Silencing of a DNA mismatch repair gene, hMLH1 gene, by promoter hypermethylation is a frequent cause of the microsatellite instability-H phenotype. Using methylation specifi...

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Detalles Bibliográficos
Autores principales:	Sakata, K, Tamura, G, Endoh, Y, Ohmura, K, Ogata, S, Motoyama, T
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375269/ https://www.ncbi.nlm.nih.gov/pubmed/11870538 http://dx.doi.org/10.1038/sj.bjc.6600076

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