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Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15–20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inacti...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375277/ https://www.ncbi.nlm.nih.gov/pubmed/11870540 http://dx.doi.org/10.1038/sj.bjc.6600148 |