Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression

Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent ‘poor immunogenicity’ previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is anot...

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Autores principales: Coventry, B J, Lee, P-L, Gibbs, D, Hart, D N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375292/
https://www.ncbi.nlm.nih.gov/pubmed/11870535
http://dx.doi.org/10.1038/sj.bjc.6600132
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author Coventry, B J
Lee, P-L
Gibbs, D
Hart, D N J
author_facet Coventry, B J
Lee, P-L
Gibbs, D
Hart, D N J
author_sort Coventry, B J
collection PubMed
description Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent ‘poor immunogenicity’ previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient. We have therefore examined CD1a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers. The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade. British Journal of Cancer (2002) 86, 546–551. DOI: 10.1038/sj/bjc/6600132 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23752922009-09-10 Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression Coventry, B J Lee, P-L Gibbs, D Hart, D N J Br J Cancer Molecular and Cellular Pathology Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent ‘poor immunogenicity’ previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient. We have therefore examined CD1a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers. The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade. British Journal of Cancer (2002) 86, 546–551. DOI: 10.1038/sj/bjc/6600132 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-02-12 /pmc/articles/PMC2375292/ /pubmed/11870535 http://dx.doi.org/10.1038/sj.bjc.6600132 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Coventry, B J
Lee, P-L
Gibbs, D
Hart, D N J
Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title_full Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title_fullStr Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title_full_unstemmed Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title_short Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
title_sort dendritic cell density and activation status in human breast cancer – cd1a, cmrf-44, cmrf-56 and cd-83 expression
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375292/
https://www.ncbi.nlm.nih.gov/pubmed/11870535
http://dx.doi.org/10.1038/sj.bjc.6600132
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