Cargando…

Analysis of CHK2 in vulval neoplasia

Structure and expression of the Rad53 homologue CHK2 were studied in vulval neoplasia. We identified the previously described silent polymorphism at codon 84 (A>G at nucleotide 252) in the germ-line of six out of 72, and somatic mutations in two out of 40 cases of vulval squamous cell carcinomas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reddy, A, Yuille, M, Sullivan, A, Repellin, C, Bell, A, Tidy, J A, Evans, D J, Farrell, P J, Gusterson, B, Gasco, M, Crook, T
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375297/ https://www.ncbi.nlm.nih.gov/pubmed/11875739 http://dx.doi.org/10.1038/sj.bjc.6600131

Ejemplares similares

E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia
por: Brooks, L A, et al.
Publicado: (2002)

Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
por: Rosenthal, A N, et al.
Publicado: (2003)

p73 is over-expressed in vulval cancer principally as the Δ2 isoform
por: O'Nions, J, et al.
Publicado: (2001)

Minichromosome maintenance (Mcm) proteins, cyclin B1 and D1, phosphohistone H3 and in situ DNA replication for functional analysis of vulval intraepithelial neoplasia
por: Davidson, E J, et al.
Publicado: (2003)

TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva
por: Rolfe, K J, et al.
Publicado: (2003)

High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia
por: Purdie, K J, et al.
Publicado: (2010)

Screening for oesophageal neoplasia in patients with head and neck cancer
por: Scherübl, H, et al.
Publicado: (2002)

Liver fatty acid binding protein expression in colorectal neoplasia
por: Lawrie, L C, et al.
Publicado: (2004)

Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis
por: Maaser, K, et al.
Publicado: (2003)

p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia
por: Rosenthal, A N, et al.
Publicado: (2000)

Increased aquaporin 1 water channel expression inhuman brain tumours
por: Saadoun, S, et al.
Publicado: (2002)

Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer
por: Damera, A, et al.
Publicado: (2003)

Cytogenetic alterations in ovarian clear cell carcinoma detected by comparative genomic hybridisation
por: Dent, J, et al.
Publicado: (2003)

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFβ2
por: Choudhury, A, et al.
Publicado: (2004)

Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
por: Weigelt, B, et al.
Publicado: (2003)

Bone metastases from breast carcinoma: histopathological – radiological correlations and prognostic features
por: James, J J, et al.
Publicado: (2003)

Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer
por: Holland, C M, et al.
Publicado: (2003)

Prognostic factors for patients with hepatic metastases from breast cancer
por: Wyld, L, et al.
Publicado: (2003)

Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
por: Abd El-Rehim, D M, et al.
Publicado: (2004)

Stromal–epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression
por: Dawson, L A, et al.
Publicado: (2004)

p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer
por: Fondevila, C, et al.
Publicado: (2004)

Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival
por: Smith, S L, et al.
Publicado: (2002)

Accumulation of uPA – PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer
por: Schneider, J, et al.
Publicado: (2003)

CpG island methylation status and mutation analysis of the RB1 gene essential promoter region and protein-binding pocket domain in nervous system tumours
por: Gonzalez-Gomez, P, et al.
Publicado: (2003)

Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen
por: Kupryjańczyk, J, et al.
Publicado: (2003)

The use of Raman spectroscopy to identify and grade prostatic adenocarcinoma in vitro
por: Crow, P, et al.
Publicado: (2003)

Thin-layer liquid-based cervical cytology and PCR for detecting and typing human papillomavirus DNA in Flemish women
por: Depuydt, C E, et al.
Publicado: (2003)

Epstein–Barr virus gene expression in human breast cancer: protagonist or passenger?
por: Xue, S A, et al.
Publicado: (2003)

Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
por: Lowrie, A G, et al.
Publicado: (2004)

CXCR4/CXCL12 expression and signalling in kidney cancer
por: Schrader, A J, et al.
Publicado: (2002)

Prolactin acts as a potent survival factor for human breast cancer cell lines
por: Perks, C M, et al.
Publicado: (2004)

High-risk human papillomavirus clearance in pregnant women: trends for lower clearance during pregnancy with a catch-up postpartum
por: Nobbenhuis, M A E, et al.
Publicado: (2002)

Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia
por: Roman-Gomez, J, et al.
Publicado: (2004)

Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells
por: Arango, D, et al.
Publicado: (2004)

Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line
por: Banerjee, R, et al.
Publicado: (2004)

Gene expression profiling identifies tumour markers potentially playing a role in uveal melanoma development
por: Zuidervaart, W, et al.
Publicado: (2003)

The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system
por: Burns, A S Y W, et al.
Publicado: (2002)

The influence of tamoxifen treatment on the oestrogen receptor in metachronous contralateral breast cancer
por: Kaas, R, et al.
Publicado: (2003)

15-PGJ(2), but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells
por: Nikitakis, N G, et al.
Publicado: (2002)

Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours
por: Clemons, M J, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_6fi2icjnvnhmdjt53i00ngvff7