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A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden
In a national case–control study in Sweden, we investigated whether in rural areas (where susceptible individuals are more prevalent than in urban areas) leukaemia risk was higher among the young children of fathers with many work contacts, as the infective hypothesis has predicted. A total of 1935...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375310/ https://www.ncbi.nlm.nih.gov/pubmed/11875735 http://dx.doi.org/10.1038/sj.bjc.6600113 |
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author | Kinlen, L Jiang, J Hemminki, K |
author_facet | Kinlen, L Jiang, J Hemminki, K |
author_sort | Kinlen, L |
collection | PubMed |
description | In a national case–control study in Sweden, we investigated whether in rural areas (where susceptible individuals are more prevalent than in urban areas) leukaemia risk was higher among the young children of fathers with many work contacts, as the infective hypothesis has predicted. A total of 1935 cases diagnosed in 1958–1998 together with 7736 age-matched (within 1 year) population controls (of whom 970 and 3880 respectively were aged 0–4) were linked to paternal occupational details as recorded in the census closest to the year of birth. Applying the two classifications of occupational contact level used in a study of rural Scotland, the odds ratios for children aged 0–4 years in the highest contact category (which includes teachers) in the most rural Swedish counties were 3.47 (95% CI 1.54, 7.85) and 1.59 (1.07, 2.38) respectively, relative to the medium and low (reference) category; no such excess was found in urban or intermediate counties. There was also a significant positive trend at ages 0–4 in the rural counties across the three levels of increasing occupational contact (P for trend 0.02 and 0.03, respectively), but again not in the urban or intermediate counties. No such effect or trend was found at ages 5–14 in any of the three county groupings. The findings confirm those of a recent study in rural Scotland, and also suggest that unusual population mixing (as occurred in Scotland as a result of the North Sea oil industry) is not a necessary requirement for the effect, since comparable mixing has not been a feature of rural Sweden. British Journal of Cancer (2002) 86, 732–737. DOI: 10.1038/sj/bjc/6600113 www.bjcancer.com © 2002 Cancer Research UK |
format | Text |
id | pubmed-2375310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23753102009-09-10 A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden Kinlen, L Jiang, J Hemminki, K Br J Cancer Epidemiology In a national case–control study in Sweden, we investigated whether in rural areas (where susceptible individuals are more prevalent than in urban areas) leukaemia risk was higher among the young children of fathers with many work contacts, as the infective hypothesis has predicted. A total of 1935 cases diagnosed in 1958–1998 together with 7736 age-matched (within 1 year) population controls (of whom 970 and 3880 respectively were aged 0–4) were linked to paternal occupational details as recorded in the census closest to the year of birth. Applying the two classifications of occupational contact level used in a study of rural Scotland, the odds ratios for children aged 0–4 years in the highest contact category (which includes teachers) in the most rural Swedish counties were 3.47 (95% CI 1.54, 7.85) and 1.59 (1.07, 2.38) respectively, relative to the medium and low (reference) category; no such excess was found in urban or intermediate counties. There was also a significant positive trend at ages 0–4 in the rural counties across the three levels of increasing occupational contact (P for trend 0.02 and 0.03, respectively), but again not in the urban or intermediate counties. No such effect or trend was found at ages 5–14 in any of the three county groupings. The findings confirm those of a recent study in rural Scotland, and also suggest that unusual population mixing (as occurred in Scotland as a result of the North Sea oil industry) is not a necessary requirement for the effect, since comparable mixing has not been a feature of rural Sweden. British Journal of Cancer (2002) 86, 732–737. DOI: 10.1038/sj/bjc/6600113 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-03-04 /pmc/articles/PMC2375310/ /pubmed/11875735 http://dx.doi.org/10.1038/sj.bjc.6600113 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Kinlen, L Jiang, J Hemminki, K A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title | A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title_full | A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title_fullStr | A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title_full_unstemmed | A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title_short | A case–control study of childhood leukaemia and paternal occupational contact level in rural Sweden |
title_sort | case–control study of childhood leukaemia and paternal occupational contact level in rural sweden |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375310/ https://www.ncbi.nlm.nih.gov/pubmed/11875735 http://dx.doi.org/10.1038/sj.bjc.6600113 |
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