Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?

Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8–61.8) with no significant differ...

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Autores principales: Shah, S, Hardy, J, Rees, E, Ling, J, Gwilliam, B, Davis, C, Broadley, K, A'Hern, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375352/
https://www.ncbi.nlm.nih.gov/pubmed/11953878
http://dx.doi.org/10.1038/sj.bjc.6600249
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author Shah, S
Hardy, J
Rees, E
Ling, J
Gwilliam, B
Davis, C
Broadley, K
A'Hern, R
author_facet Shah, S
Hardy, J
Rees, E
Ling, J
Gwilliam, B
Davis, C
Broadley, K
A'Hern, R
author_sort Shah, S
collection PubMed
description Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8–61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6–9 (corrected serum calcium ⩽2.6 mmol l(−1)) across all groups. British Journal of Cancer (2002) 86, 1235–1237. DOI: 10.1038/sj/bjc/6600249 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23753522009-09-10 Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia? Shah, S Hardy, J Rees, E Ling, J Gwilliam, B Davis, C Broadley, K A'Hern, R Br J Cancer Clinical Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8–61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6–9 (corrected serum calcium ⩽2.6 mmol l(−1)) across all groups. British Journal of Cancer (2002) 86, 1235–1237. DOI: 10.1038/sj/bjc/6600249 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-04-22 /pmc/articles/PMC2375352/ /pubmed/11953878 http://dx.doi.org/10.1038/sj.bjc.6600249 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Shah, S
Hardy, J
Rees, E
Ling, J
Gwilliam, B
Davis, C
Broadley, K
A'Hern, R
Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title_full Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title_fullStr Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title_full_unstemmed Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title_short Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
title_sort is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375352/
https://www.ncbi.nlm.nih.gov/pubmed/11953878
http://dx.doi.org/10.1038/sj.bjc.6600249
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