Cargando…

Pregnancy and risk of renal cell cancer: a population-based study in Sweden

Epidemiological findings indicate that hormonal influences may play a role in the etiology of renal cell cancer (RCC). The possible effect of childbearing remains enigmatic; while some investigators have reported a positive association between number of births and renal cell cancer risk, others have...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambe, M, Lindblad, P, Wuu, J, Remler, R, Hsieh, C-c
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375385/
https://www.ncbi.nlm.nih.gov/pubmed/11986775
http://dx.doi.org/10.1038/sj.bjc.6600263
_version_ 1782154644029440000
author Lambe, M
Lindblad, P
Wuu, J
Remler, R
Hsieh, C-c
author_facet Lambe, M
Lindblad, P
Wuu, J
Remler, R
Hsieh, C-c
author_sort Lambe, M
collection PubMed
description Epidemiological findings indicate that hormonal influences may play a role in the etiology of renal cell cancer (RCC). The possible effect of childbearing remains enigmatic; while some investigators have reported a positive association between number of births and renal cell cancer risk, others have not. A case–control study, nested within a nation-wide Fertility Register covering Swedish women born 1925 and later, was undertaken to explore possible associations between parity and age at first birth and the risk of renal cell cancer. Among these women a total of 1465 cases of RCC were identified in the Swedish Cancer Register between 1958 and 1992 and information on the number of live childbirths and age at each birth was obtained by linkage to the Fertility Database. For each case, five age-matched controls were randomly selected from the same register. Compared to nulliparous women, ever-parous women were at a 40% increased risk of RCC (Odds Ratio [OR]=1.42; 95% CI 1.19-1.69). The corresponding OR for women of high parity (five or more live births) was 1.91 (95% CI 1.40–2.62). After controlling for age at first birth among parous women, each additional birth was associated with a 15% increase in risk (OR=1.15; 95% CI 1.08–1.22). The observed positive association between parity and renal cell cancer risk is unlikely to be fully explained by uncontrolled confounding, but warrants further evaluation in large studies, with allowance for body mass index. British Journal of Cancer (2002) 86, 1425–1429. DOI: 10.1038/sj/bjc/6600263 www.bjcancer.com © 2002 Cancer Research UK
format Text
id pubmed-2375385
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23753852009-09-10 Pregnancy and risk of renal cell cancer: a population-based study in Sweden Lambe, M Lindblad, P Wuu, J Remler, R Hsieh, C-c Br J Cancer Epidemiology Epidemiological findings indicate that hormonal influences may play a role in the etiology of renal cell cancer (RCC). The possible effect of childbearing remains enigmatic; while some investigators have reported a positive association between number of births and renal cell cancer risk, others have not. A case–control study, nested within a nation-wide Fertility Register covering Swedish women born 1925 and later, was undertaken to explore possible associations between parity and age at first birth and the risk of renal cell cancer. Among these women a total of 1465 cases of RCC were identified in the Swedish Cancer Register between 1958 and 1992 and information on the number of live childbirths and age at each birth was obtained by linkage to the Fertility Database. For each case, five age-matched controls were randomly selected from the same register. Compared to nulliparous women, ever-parous women were at a 40% increased risk of RCC (Odds Ratio [OR]=1.42; 95% CI 1.19-1.69). The corresponding OR for women of high parity (five or more live births) was 1.91 (95% CI 1.40–2.62). After controlling for age at first birth among parous women, each additional birth was associated with a 15% increase in risk (OR=1.15; 95% CI 1.08–1.22). The observed positive association between parity and renal cell cancer risk is unlikely to be fully explained by uncontrolled confounding, but warrants further evaluation in large studies, with allowance for body mass index. British Journal of Cancer (2002) 86, 1425–1429. DOI: 10.1038/sj/bjc/6600263 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-05-06 /pmc/articles/PMC2375385/ /pubmed/11986775 http://dx.doi.org/10.1038/sj.bjc.6600263 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Lambe, M
Lindblad, P
Wuu, J
Remler, R
Hsieh, C-c
Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title_full Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title_fullStr Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title_full_unstemmed Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title_short Pregnancy and risk of renal cell cancer: a population-based study in Sweden
title_sort pregnancy and risk of renal cell cancer: a population-based study in sweden
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375385/
https://www.ncbi.nlm.nih.gov/pubmed/11986775
http://dx.doi.org/10.1038/sj.bjc.6600263
work_keys_str_mv AT lambem pregnancyandriskofrenalcellcancerapopulationbasedstudyinsweden
AT lindbladp pregnancyandriskofrenalcellcancerapopulationbasedstudyinsweden
AT wuuj pregnancyandriskofrenalcellcancerapopulationbasedstudyinsweden
AT remlerr pregnancyandriskofrenalcellcancerapopulationbasedstudyinsweden
AT hsiehcc pregnancyandriskofrenalcellcancerapopulationbasedstudyinsweden