Cargando…

Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours

An important determinant of cellular resistance to chemotherapeutic O(6)-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O(6)-position of guanine in DNA. This is achieved by a specific DNA repair enzyme O(6)-alkylg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clemons, M J, Bibby, M C, El Teraifi, H, Forster, G, Kelly, J, Banerjee, S, Cadman, B, Ryder, W D J, Howell, A, Margison, G P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375409/ https://www.ncbi.nlm.nih.gov/pubmed/12087469 http://dx.doi.org/10.1038/sj.bjc.6600324

Ejemplares similares

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
por: Lees, N P, et al.
Publicado: (2002)

O6-alkylguanine-DNA-alkyltransferase activity and nitrosourea sensitivity in human cancer cell lines.
por: Walker, M. C., et al.
Publicado: (1992)

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.
por: Baer, J. C., et al.
Publicado: (1993)

Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide.
por: Lee, S. M., et al.
Publicado: (1994)

Expression of O (6)-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients
por: Saad, Abir A., et al.
Publicado: (2010)

Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas.
por: Harris, L. C., et al.
Publicado: (1993)

Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation.
por: Lee, S. M., et al.
Publicado: (1992)

Dosage and cycle effects of dacarbazine (DTIC) and fotemustine on O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells.
por: Lee, S. M., et al.
Publicado: (1993)

Dose finding and O(6)-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies
por: Geoerger, B, et al.
Publicado: (2005)

Marked inactivation of O(6)-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
por: Tolcher, A W, et al.
Publicado: (2003)

Lesion-specific DNA-binding and repair activities of human O(6)-alkylguanine DNA alkyltransferase
por: Melikishvili, Manana, et al.
Publicado: (2012)

Cooperative cluster formation, DNA bending and base-flipping by O(6)-alkylguanine-DNA alkyltransferase
por: Tessmer, Ingrid, et al.
Publicado: (2012)

Effects of Inhibition of O(6)‐Alkylguanine‐DNA Alkyltransferase in Rats on Carcinogenesis by Methylnitrosourea and Ethylnitrosourea
por: Lijinsky, William, et al.
Publicado: (1994)

O(6)-alkylguanine-DNA Alkyltransferases in Microbes Living on the Edge: From Stability to Applicability
por: Mattossovich, Rosanna, et al.
Publicado: (2020)

Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma.
por: Lee, S. M., et al.
Publicado: (1992)

Repair of O(6)-methylguanine adducts in human telomeric G-quadruplex DNA by O(6)-alkylguanine-DNA alkyltransferase
por: Hellman, Lance M., et al.
Publicado: (2014)

Intra-tumoural microvessel density in human solid tumours
por: Hasan, J, et al.
Publicado: (2002)

Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
por: Pegg, A E, et al.
Publicado: (1985)

The embedded tumour: host physiology is important for the evaluation of tumour growth
por: van Leeuwen, I M M, et al.
Publicado: (2003)

ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours
por: Vicent, S, et al.
Publicado: (2004)

The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells
por: Kim, M, et al.
Publicado: (2003)

Sensitive detection of tumour cells in effusions by combining cytology and fluorescence in situ hybridisation (FISH)
por: Fiegl, M, et al.
Publicado: (2004)

Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers
por: Lee, K T, et al.
Publicado: (2004)

Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation
por: McKeown, S R, et al.
Publicado: (2003)

Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours
por: Zurita, A J, et al.
Publicado: (2003)

A model for co-expression pattern analysis of genes implicated in angiogenesis and tumour cell invasion in cervical cancer
por: Van Trappen, P O, et al.
Publicado: (2002)

Prognostic impact of chromosomal aberrations in Ewing tumours
por: Hattinger, C M, et al.
Publicado: (2002)

DNA topoisomerase I and II expression in drug resistantgerm cell tumours
por: Berney, D M, et al.
Publicado: (2002)

Galanin and galanin receptor expression in neuroblastic tumours: correlation with their differentiation status
por: Perel, Y, et al.
Publicado: (2002)

Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
por: Lewis, M P, et al.
Publicado: (2004)

Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer
por: Mamot, C, et al.
Publicado: (2003)

Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage
por: Pardo, F S, et al.
Publicado: (2004)

Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications
por: Ferrandina, G, et al.
Publicado: (2002)

RARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma
por: Shyu, R-Y, et al.
Publicado: (2003)

Effect of neoadjuvant treatment with anastrozole on tumour histology in postmenopausal women with large operable breast cancer
por: Anderson, T J, et al.
Publicado: (2002)

The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous system
por: Burns, A S Y W, et al.
Publicado: (2002)

Discrimination between uterine serous papillary carcinomas and ovarian serous papillary tumours by gene expression profiling
por: Santin, A D, et al.
Publicado: (2004)

Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumours
por: Marques, A R, et al.
Publicado: (2004)

Rapid detection of allelic losses in brain tumours using microsatellite repeat markers and high-performance liquid chromatography
por: Chernova, O B, et al.
Publicado: (2003)

Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients
por: Weigelt, B, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_0nel0prq5ffue34sscv7h4f0kq