Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo,...

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Detalles Bibliográficos
Autores principales: Brown, N J, Staton, C A, Rodgers, G R, Corke, K P, Underwood, J C E, Lewis, C E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375410/
https://www.ncbi.nlm.nih.gov/pubmed/12087471
http://dx.doi.org/10.1038/sj.bjc.6600320
Descripción
Sumario:We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model. British Journal of Cancer (2002) 86, 1813–1816. doi:10.1038/sj.bjc.6600320 www.bjcancer.com © 2002 Cancer Research UK

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