Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo,...

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Autores principales: Brown, N J, Staton, C A, Rodgers, G R, Corke, K P, Underwood, J C E, Lewis, C E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375410/
https://www.ncbi.nlm.nih.gov/pubmed/12087471
http://dx.doi.org/10.1038/sj.bjc.6600320
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author Brown, N J
Staton, C A
Rodgers, G R
Corke, K P
Underwood, J C E
Lewis, C E
author_facet Brown, N J
Staton, C A
Rodgers, G R
Corke, K P
Underwood, J C E
Lewis, C E
author_sort Brown, N J
collection PubMed
description We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model. British Journal of Cancer (2002) 86, 1813–1816. doi:10.1038/sj.bjc.6600320 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23754102009-09-10 Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model Brown, N J Staton, C A Rodgers, G R Corke, K P Underwood, J C E Lewis, C E Br J Cancer Experimental Therapeutics We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model. British Journal of Cancer (2002) 86, 1813–1816. doi:10.1038/sj.bjc.6600320 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-06-05 /pmc/articles/PMC2375410/ /pubmed/12087471 http://dx.doi.org/10.1038/sj.bjc.6600320 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Brown, N J
Staton, C A
Rodgers, G R
Corke, K P
Underwood, J C E
Lewis, C E
Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title_full Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title_fullStr Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title_full_unstemmed Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title_short Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
title_sort fibrinogen e fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375410/
https://www.ncbi.nlm.nih.gov/pubmed/12087471
http://dx.doi.org/10.1038/sj.bjc.6600320
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