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Inactivation of O(6)-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers

Promoter hypermethylation of CpG islands in tumour suppressor genes can lead to transcriptional inactivation. To investigate the association between methylation and expression at O(6)-methylguanine-DNA methyltransferase, we performed methylation-specific PCR and immunohistochemistry in 149 gastric c...

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Detalles Bibliográficos
Autores principales:	Bae, S I, Lee, H S, Kim, S H, Kim, W H
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2002
Materias:	Molecular and Cellular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375420/ https://www.ncbi.nlm.nih.gov/pubmed/12085181 http://dx.doi.org/10.1038/sj.bjc.6600372

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