Tumour microvessel density as predictor of chemotherapy response in breast cancer patients

The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotr...

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Autores principales: Tynninen, O, Sjöström, J, von Boguslawski, K, Bengtsson, N O, Heikkilä, R, Malmström, P, Østenstad, B, Wist, E, Valvere, V, Saksela, E, Paavonen, T, Blomqvist, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375425/
https://www.ncbi.nlm.nih.gov/pubmed/12085184
http://dx.doi.org/10.1038/sj.bjc.6600325
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author Tynninen, O
Sjöström, J
von Boguslawski, K
Bengtsson, N O
Heikkilä, R
Malmström, P
Østenstad, B
Wist, E
Valvere, V
Saksela, E
Paavonen, T
Blomqvist, C
author_facet Tynninen, O
Sjöström, J
von Boguslawski, K
Bengtsson, N O
Heikkilä, R
Malmström, P
Østenstad, B
Wist, E
Valvere, V
Saksela, E
Paavonen, T
Blomqvist, C
author_sort Tynninen, O
collection PubMed
description The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer. British Journal of Cancer (2002) 86, 1905–1908. doi:10.1038/sj.bjc.6600325 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23754252009-09-10 Tumour microvessel density as predictor of chemotherapy response in breast cancer patients Tynninen, O Sjöström, J von Boguslawski, K Bengtsson, N O Heikkilä, R Malmström, P Østenstad, B Wist, E Valvere, V Saksela, E Paavonen, T Blomqvist, C Br J Cancer Molecular and Cellular Pathology The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer. British Journal of Cancer (2002) 86, 1905–1908. doi:10.1038/sj.bjc.6600325 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-06-17 /pmc/articles/PMC2375425/ /pubmed/12085184 http://dx.doi.org/10.1038/sj.bjc.6600325 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Tynninen, O
Sjöström, J
von Boguslawski, K
Bengtsson, N O
Heikkilä, R
Malmström, P
Østenstad, B
Wist, E
Valvere, V
Saksela, E
Paavonen, T
Blomqvist, C
Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title_full Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title_fullStr Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title_full_unstemmed Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title_short Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
title_sort tumour microvessel density as predictor of chemotherapy response in breast cancer patients
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375425/
https://www.ncbi.nlm.nih.gov/pubmed/12085184
http://dx.doi.org/10.1038/sj.bjc.6600325
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