Somatic glypican 3 (GPC3) mutations in Wilms' tumour

Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumo...

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Autores principales: White, G R M, Kelsey, A M, Varley, J M, Birch, J M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375433/
https://www.ncbi.nlm.nih.gov/pubmed/12085187
http://dx.doi.org/10.1038/sj.bjc.6600417
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author White, G R M
Kelsey, A M
Varley, J M
Birch, J M
author_facet White, G R M
Kelsey, A M
Varley, J M
Birch, J M
author_sort White, G R M
collection PubMed
description Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development. British Journal of Cancer (2002) 86, 1920–1922. doi:10.1038/sj.bjc.6600417 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23754332009-09-10 Somatic glypican 3 (GPC3) mutations in Wilms' tumour White, G R M Kelsey, A M Varley, J M Birch, J M Br J Cancer Genetics and Genomics Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development. British Journal of Cancer (2002) 86, 1920–1922. doi:10.1038/sj.bjc.6600417 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-06-17 /pmc/articles/PMC2375433/ /pubmed/12085187 http://dx.doi.org/10.1038/sj.bjc.6600417 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
White, G R M
Kelsey, A M
Varley, J M
Birch, J M
Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title_full Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title_fullStr Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title_full_unstemmed Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title_short Somatic glypican 3 (GPC3) mutations in Wilms' tumour
title_sort somatic glypican 3 (gpc3) mutations in wilms' tumour
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375433/
https://www.ncbi.nlm.nih.gov/pubmed/12085187
http://dx.doi.org/10.1038/sj.bjc.6600417
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