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Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: Towards the design of higher-affinity inhibitors

BACKGROUND: DNA polymerase beta (pol beta), the error-prone DNA polymerase of single-stranded DNA break repair as well as base excision repair pathways, is overexpressed in several tumors and takes part in chemotherapeutic agent resistance, like that of cisplatin, through translesion synthesis. For...

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Detalles Bibliográficos
Autores principales:	Hazan, Corinne, Boudsocq, François, Gervais, Virginie, Saurel, Olivier, Ciais, Marion, Cazaux, Christophe, Czaplicki, Jerzy, Milon, Alain
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375893/ https://www.ncbi.nlm.nih.gov/pubmed/18416825 http://dx.doi.org/10.1186/1472-6807-8-22

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