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Local conservation scores without a priori assumptions on neutral substitution rates

BACKGROUND: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed that about half of the experimentally verified functional elements found in non-coding DNA were classified as unconstrai...

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Detalles Bibliográficos
Autores principales:	Dingel, Janis, Hanus, Pavol, Leonardi, Niccolò, Hagenauer, Joachim, Zech, Jürgen, Mueller, Jakob C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375903/ https://www.ncbi.nlm.nih.gov/pubmed/18405366 http://dx.doi.org/10.1186/1471-2105-9-190

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