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Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines
Transformed cells have been documented to be methionine-dependent, suggesting that inhibition of methionine synthesis might be useful for cancer therapy. Methylenetetrahydrofolate reductase synthesises 5-methyltetrahydrofolate, the methyl donor utilised in methionine synthesis from homocysteine by v...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376111/ https://www.ncbi.nlm.nih.gov/pubmed/12107847 http://dx.doi.org/10.1038/sj.bjc.6600459 |