Targeting the cell cycle for cancer therapy

Most if not all neoplasias show a directly or indirectly deregulated cell cycle. Targeting its regulatory molecules, the cyclin-dependent kinases, as a therapeutic mode to develop new anticancer drugs, is being currently explored in both academia and pharmaceutical companies. The development of new...

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Detalles Bibliográficos
Autor principal: Carnero, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376115/
https://www.ncbi.nlm.nih.gov/pubmed/12107831
http://dx.doi.org/10.1038/sj.bjc.6600458
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author Carnero, A
author_facet Carnero, A
author_sort Carnero, A
collection PubMed
description Most if not all neoplasias show a directly or indirectly deregulated cell cycle. Targeting its regulatory molecules, the cyclin-dependent kinases, as a therapeutic mode to develop new anticancer drugs, is being currently explored in both academia and pharmaceutical companies. The development of new compounds is being focused on the many features of the cell cycle with promising preclinical data in most fields. Moreover, a few compounds have entered clinical trials with excellent results maintaining the high hopes. Thus, although too early to provide a cell cycle target based new commercial drug, there is no doubt that it will be an excellent source of new anticancer compounds. British Journal of Cancer (2002) 87, 129–133. doi:10.1038/sj.bjc.6600458 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23761152009-09-10 Targeting the cell cycle for cancer therapy Carnero, A Br J Cancer Review Article Most if not all neoplasias show a directly or indirectly deregulated cell cycle. Targeting its regulatory molecules, the cyclin-dependent kinases, as a therapeutic mode to develop new anticancer drugs, is being currently explored in both academia and pharmaceutical companies. The development of new compounds is being focused on the many features of the cell cycle with promising preclinical data in most fields. Moreover, a few compounds have entered clinical trials with excellent results maintaining the high hopes. Thus, although too early to provide a cell cycle target based new commercial drug, there is no doubt that it will be an excellent source of new anticancer compounds. British Journal of Cancer (2002) 87, 129–133. doi:10.1038/sj.bjc.6600458 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-07-15 2002-07-02 /pmc/articles/PMC2376115/ /pubmed/12107831 http://dx.doi.org/10.1038/sj.bjc.6600458 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Carnero, A
Targeting the cell cycle for cancer therapy
title Targeting the cell cycle for cancer therapy
title_full Targeting the cell cycle for cancer therapy
title_fullStr Targeting the cell cycle for cancer therapy
title_full_unstemmed Targeting the cell cycle for cancer therapy
title_short Targeting the cell cycle for cancer therapy
title_sort targeting the cell cycle for cancer therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376115/
https://www.ncbi.nlm.nih.gov/pubmed/12107831
http://dx.doi.org/10.1038/sj.bjc.6600458
work_keys_str_mv AT carneroa targetingthecellcycleforcancertherapy

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