Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Lees, N P, Harrison, K L, Hill, E, Hall, C N, Margison, G P, Povey, A C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376118/
https://www.ncbi.nlm.nih.gov/pubmed/12107837
http://dx.doi.org/10.1038/sj.bjc.6600455
Descripción
Sumario:In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis. British Journal of Cancer (2002) 87, 168–170. doi:10.1038/sj.bjc.6600455 www.bjcancer.com © 2002 Cancer Research UK

Ejemplares similares