Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be imp...

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Autores principales: Lees, N P, Harrison, K L, Hill, E, Hall, C N, Margison, G P, Povey, A C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376118/
https://www.ncbi.nlm.nih.gov/pubmed/12107837
http://dx.doi.org/10.1038/sj.bjc.6600455
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author Lees, N P
Harrison, K L
Hill, E
Hall, C N
Margison, G P
Povey, A C
author_facet Lees, N P
Harrison, K L
Hill, E
Hall, C N
Margison, G P
Povey, A C
author_sort Lees, N P
collection PubMed
description In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis. British Journal of Cancer (2002) 87, 168–170. doi:10.1038/sj.bjc.6600455 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23761182009-09-10 Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum Lees, N P Harrison, K L Hill, E Hall, C N Margison, G P Povey, A C Br J Cancer Molecular and Cellular Pathology In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis. British Journal of Cancer (2002) 87, 168–170. doi:10.1038/sj.bjc.6600455 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-07-15 2002-07-02 /pmc/articles/PMC2376118/ /pubmed/12107837 http://dx.doi.org/10.1038/sj.bjc.6600455 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Lees, N P
Harrison, K L
Hill, E
Hall, C N
Margison, G P
Povey, A C
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title_full Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title_fullStr Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title_full_unstemmed Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title_short Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum
title_sort longitudinal variation in o(6)-alkylguanine dna-alkyltransferase activity in the human colon and rectum
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376118/
https://www.ncbi.nlm.nih.gov/pubmed/12107837
http://dx.doi.org/10.1038/sj.bjc.6600455
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