Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease

Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20×10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackhall, F H, Atkinson, A D, Maaya, M B, Ryder, W D J, Horne, G, Brison, D R, Lieberman, B A, Radford, J A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376135/
https://www.ncbi.nlm.nih.gov/pubmed/12177773
http://dx.doi.org/10.1038/sj.bjc.6600483
_version_ 1782154698314219520
author Blackhall, F H
Atkinson, A D
Maaya, M B
Ryder, W D J
Horne, G
Brison, D R
Lieberman, B A
Radford, J A
author_facet Blackhall, F H
Atkinson, A D
Maaya, M B
Ryder, W D J
Horne, G
Brison, D R
Lieberman, B A
Radford, J A
author_sort Blackhall, F H
collection PubMed
description Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20×10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation. British Journal of Cancer (2002) 87, 381–384. doi:10.1038/sj.bjc.6600483 www.bjcancer.com © 2002 Cancer Research UK
format Text
id pubmed-2376135
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23761352009-09-10 Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease Blackhall, F H Atkinson, A D Maaya, M B Ryder, W D J Horne, G Brison, D R Lieberman, B A Radford, J A Br J Cancer Clinical Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20×10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation. British Journal of Cancer (2002) 87, 381–384. doi:10.1038/sj.bjc.6600483 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-08-12 /pmc/articles/PMC2376135/ /pubmed/12177773 http://dx.doi.org/10.1038/sj.bjc.6600483 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Blackhall, F H
Atkinson, A D
Maaya, M B
Ryder, W D J
Horne, G
Brison, D R
Lieberman, B A
Radford, J A
Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title_full Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title_fullStr Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title_full_unstemmed Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title_short Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease
title_sort semen cryopreservation, utilisation and reproductive outcome in men treated for hodgkin's disease
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376135/
https://www.ncbi.nlm.nih.gov/pubmed/12177773
http://dx.doi.org/10.1038/sj.bjc.6600483
work_keys_str_mv AT blackhallfh semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT atkinsonad semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT maayamb semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT ryderwdj semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT horneg semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT brisondr semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT liebermanba semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease
AT radfordja semencryopreservationutilisationandreproductiveoutcomeinmentreatedforhodgkinsdisease

Ejemplares similares