Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma

The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing oesophagectomy for high grade dysplasia...

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Autores principales: Coyle, P, Mathew, G, Game, P A, Myers, J C, Philcox, J C, Rofe, A M, Jamieson, G G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Molecular and Cellular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376153/
https://www.ncbi.nlm.nih.gov/pubmed/12189552
http://dx.doi.org/10.1038/sj.bjc.6600473
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author Coyle, P
Mathew, G
Game, P A
Myers, J C
Philcox, J C
Rofe, A M
Jamieson, G G
author_facet Coyle, P
Mathew, G
Game, P A
Myers, J C
Philcox, J C
Rofe, A M
Jamieson, G G
author_sort Coyle, P
collection PubMed
description The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing oesophagectomy for high grade dysplasia/adenocarcinoma and in biopsies from patients with Barrett's syndrome. In 10 cancer patients, metallothionein concentrations in adenocarcinoma were not significantly different from normal oesophagus, although six had elevated metallothionein concentrations in the metaplastic tissue bordering the adenocarcinoma. In 17 out of 20 non-cancer patients with Barrett's epithelium, metallothionein was significantly increased by 108% (P<0.004). There was no association between the metallothionein levels in Barrett's epithelium and the presence of inflammatory cells, metaplasia or dysplasia. Metallothionein is a marker of progression from normal to Barrett's epithelium but is not increased in oesophageal adenocarcinoma. British Journal of Cancer (2002) 87, 533–536. doi:10.1038/sj.bjc.6600473 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23761532009-09-10 Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma Coyle, P Mathew, G Game, P A Myers, J C Philcox, J C Rofe, A M Jamieson, G G Br J Cancer Molecular and Cellular Pathology The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively determined in resected tissues from patients undergoing oesophagectomy for high grade dysplasia/adenocarcinoma and in biopsies from patients with Barrett's syndrome. In 10 cancer patients, metallothionein concentrations in adenocarcinoma were not significantly different from normal oesophagus, although six had elevated metallothionein concentrations in the metaplastic tissue bordering the adenocarcinoma. In 17 out of 20 non-cancer patients with Barrett's epithelium, metallothionein was significantly increased by 108% (P<0.004). There was no association between the metallothionein levels in Barrett's epithelium and the presence of inflammatory cells, metaplasia or dysplasia. Metallothionein is a marker of progression from normal to Barrett's epithelium but is not increased in oesophageal adenocarcinoma. British Journal of Cancer (2002) 87, 533–536. doi:10.1038/sj.bjc.6600473 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-08-27 /pmc/articles/PMC2376153/ /pubmed/12189552 http://dx.doi.org/10.1038/sj.bjc.6600473 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Coyle, P
Mathew, G
Game, P A
Myers, J C
Philcox, J C
Rofe, A M
Jamieson, G G
Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title_full Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title_fullStr Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title_full_unstemmed Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title_short Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma
title_sort metallothionein in human oesophagus, barrett's epithelium and adenocarcinoma
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376153/
https://www.ncbi.nlm.nih.gov/pubmed/12189552
http://dx.doi.org/10.1038/sj.bjc.6600473
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AT rofeam metallothioneininhumanoesophagusbarrettsepitheliumandadenocarcinoma
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