Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach

Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair genes, in particular MLH1, MSH2 and MSH6. Here we describe the application of a novel technique for the detection of genomic deletions in MLH1 and MSH2. This method, called...

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Detalles Bibliográficos
Autores principales: Gille, J J P, Hogervorst, F B L, Pals, G, Wijnen, JTh, van Schooten, R J, Dommering, C J, Meijer, G A, Craanen, M E, Nederlof, P M, de Jong, D, McElgunn, C J, Schouten, J P, Menko, F H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376172/
https://www.ncbi.nlm.nih.gov/pubmed/12373605
http://dx.doi.org/10.1038/sj.bjc.6600565

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