Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither ge...

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Detalles Bibliográficos
Autores principales: Özdağ, H, Batley, S J, Försti, A, Iyer, N G, Daigo, Y, Boutell, J, Arends, M J, Ponder, B A J, Kouzarides, T, Caldas, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376187/
https://www.ncbi.nlm.nih.gov/pubmed/12402157
http://dx.doi.org/10.1038/sj.bjc.6600554
Descripción
Sumario:In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. British Journal of Cancer (2002) 87, 1162–1165. doi:10.1038/sj.bjc.6600554 www.bjcancer.com © 2002 Cancer Research UK

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