Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither ge...

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Autores principales: Özdağ, H, Batley, S J, Försti, A, Iyer, N G, Daigo, Y, Boutell, J, Arends, M J, Ponder, B A J, Kouzarides, T, Caldas, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376187/
https://www.ncbi.nlm.nih.gov/pubmed/12402157
http://dx.doi.org/10.1038/sj.bjc.6600554
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author Özdağ, H
Batley, S J
Försti, A
Iyer, N G
Daigo, Y
Boutell, J
Arends, M J
Ponder, B A J
Kouzarides, T
Caldas, C
author_facet Özdağ, H
Batley, S J
Försti, A
Iyer, N G
Daigo, Y
Boutell, J
Arends, M J
Ponder, B A J
Kouzarides, T
Caldas, C
author_sort Özdağ, H
collection PubMed
description In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. British Journal of Cancer (2002) 87, 1162–1165. doi:10.1038/sj.bjc.6600554 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23761872009-09-10 Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours Özdağ, H Batley, S J Försti, A Iyer, N G Daigo, Y Boutell, J Arends, M J Ponder, B A J Kouzarides, T Caldas, C Br J Cancer Genetics and Genomics In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers. British Journal of Cancer (2002) 87, 1162–1165. doi:10.1038/sj.bjc.6600554 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-11-04 2002-11-04 /pmc/articles/PMC2376187/ /pubmed/12402157 http://dx.doi.org/10.1038/sj.bjc.6600554 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Özdağ, H
Batley, S J
Försti, A
Iyer, N G
Daigo, Y
Boutell, J
Arends, M J
Ponder, B A J
Kouzarides, T
Caldas, C
Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title_full Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title_fullStr Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title_full_unstemmed Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title_short Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours
title_sort mutation analysis of cbp and pcaf reveals rare inactivating mutations in cancer cell lines but not in primary tumours
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376187/
https://www.ncbi.nlm.nih.gov/pubmed/12402157
http://dx.doi.org/10.1038/sj.bjc.6600554
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