Role of genetic polymorphisms in tumour angiogenesis

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter pro...

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Autores principales: Balasubramanian, S P, Brown, N J, Reed, M W R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376194/
https://www.ncbi.nlm.nih.gov/pubmed/12402142
http://dx.doi.org/10.1038/sj.bjc.6600625
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author Balasubramanian, S P
Brown, N J
Reed, M W R
author_facet Balasubramanian, S P
Brown, N J
Reed, M W R
author_sort Balasubramanian, S P
collection PubMed
description Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed. British Journal of Cancer (2002) 87, 1057–1065. doi:10.1038/sj.bjc.6600625 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23761942009-09-10 Role of genetic polymorphisms in tumour angiogenesis Balasubramanian, S P Brown, N J Reed, M W R Br J Cancer Review Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed. British Journal of Cancer (2002) 87, 1057–1065. doi:10.1038/sj.bjc.6600625 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-11-04 2002-11-04 /pmc/articles/PMC2376194/ /pubmed/12402142 http://dx.doi.org/10.1038/sj.bjc.6600625 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Balasubramanian, S P
Brown, N J
Reed, M W R
Role of genetic polymorphisms in tumour angiogenesis
title Role of genetic polymorphisms in tumour angiogenesis
title_full Role of genetic polymorphisms in tumour angiogenesis
title_fullStr Role of genetic polymorphisms in tumour angiogenesis
title_full_unstemmed Role of genetic polymorphisms in tumour angiogenesis
title_short Role of genetic polymorphisms in tumour angiogenesis
title_sort role of genetic polymorphisms in tumour angiogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376194/
https://www.ncbi.nlm.nih.gov/pubmed/12402142
http://dx.doi.org/10.1038/sj.bjc.6600625
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AT brownnj roleofgeneticpolymorphismsintumourangiogenesis
AT reedmwr roleofgeneticpolymorphismsintumourangiogenesis

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