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Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers

In spite of the apparent improvement in outcome in locally advanced breast cancer, the prognosis remains dismal in many patients. The aim of this study was to define prognostic subgroups within this heterogeneous entity. Between 1990 and 1999, 104 consecutive patients with locally advanced breast ca...

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Autores principales: Brenner, B, Siris, N, Rakowsky, E, Fenig, E, Sulkes, A, Lurie, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376279/
https://www.ncbi.nlm.nih.gov/pubmed/12454769
http://dx.doi.org/10.1038/sj.bjc.6600616
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author Brenner, B
Siris, N
Rakowsky, E
Fenig, E
Sulkes, A
Lurie, H
author_facet Brenner, B
Siris, N
Rakowsky, E
Fenig, E
Sulkes, A
Lurie, H
author_sort Brenner, B
collection PubMed
description In spite of the apparent improvement in outcome in locally advanced breast cancer, the prognosis remains dismal in many patients. The aim of this study was to define prognostic subgroups within this heterogeneous entity. Between 1990 and 1999, 104 consecutive patients with locally advanced breast cancer were treated by a multimodality programme consisting of 4–6 courses of CAF induction chemotherapy followed by surgery, breast-conserving when feasible. In most cases, chemotherapy was then resumed, up to a total of eight courses, followed by locoregional radiation therapy. Patients with hormone receptor-positive tumours received tamoxifen (20 mg day(−1)) for 5 years. At a median follow-up of 57 months, the 5-year overall survival for the entire group and the disease-free survival for the 94 operated patients were 65% and 53%, respectively. Univariate analysis identified 10 prognostic factors of overall and disease-free survival, of which four retained significance on multivariate analysis: inflammatory breast cancer (P=0.0000, P=0.0004, respectively), baseline tumour markers (P=0.003 for both), post-chemotherapy number of involved nodes (P=0.003; P=0.017) and extracapsular spread (P=0.052; P=0.014). In conclusion, besides inflammatory features, baseline tumour markers and post-chemotherapy nodal status are strong predictors of outcome in locally advanced breast cancer. British Journal of Cancer (2002) 87, 1404–1410. doi:10.1038/sj.bjc.6600616 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23762792009-09-10 Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers Brenner, B Siris, N Rakowsky, E Fenig, E Sulkes, A Lurie, H Br J Cancer Molecular and Cellular Pathology In spite of the apparent improvement in outcome in locally advanced breast cancer, the prognosis remains dismal in many patients. The aim of this study was to define prognostic subgroups within this heterogeneous entity. Between 1990 and 1999, 104 consecutive patients with locally advanced breast cancer were treated by a multimodality programme consisting of 4–6 courses of CAF induction chemotherapy followed by surgery, breast-conserving when feasible. In most cases, chemotherapy was then resumed, up to a total of eight courses, followed by locoregional radiation therapy. Patients with hormone receptor-positive tumours received tamoxifen (20 mg day(−1)) for 5 years. At a median follow-up of 57 months, the 5-year overall survival for the entire group and the disease-free survival for the 94 operated patients were 65% and 53%, respectively. Univariate analysis identified 10 prognostic factors of overall and disease-free survival, of which four retained significance on multivariate analysis: inflammatory breast cancer (P=0.0000, P=0.0004, respectively), baseline tumour markers (P=0.003 for both), post-chemotherapy number of involved nodes (P=0.003; P=0.017) and extracapsular spread (P=0.052; P=0.014). In conclusion, besides inflammatory features, baseline tumour markers and post-chemotherapy nodal status are strong predictors of outcome in locally advanced breast cancer. British Journal of Cancer (2002) 87, 1404–1410. doi:10.1038/sj.bjc.6600616 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-12-02 2002-11-26 /pmc/articles/PMC2376279/ /pubmed/12454769 http://dx.doi.org/10.1038/sj.bjc.6600616 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Brenner, B
Siris, N
Rakowsky, E
Fenig, E
Sulkes, A
Lurie, H
Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title_full Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title_fullStr Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title_full_unstemmed Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title_short Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
title_sort prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376279/
https://www.ncbi.nlm.nih.gov/pubmed/12454769
http://dx.doi.org/10.1038/sj.bjc.6600616
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