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Dermatofibrosarcoma protuberans treated by micrographic surgery
Dermatofibrosarcoma protuberans is an uncommon cutaneous tumour which rarely metastasises. However, local recurrence following apparently adequate surgical excision is well recognised, presumably as a result of sub-clinical contiguous growth, for which micrographically controlled excision would be a...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376302/ https://www.ncbi.nlm.nih.gov/pubmed/12454766 http://dx.doi.org/10.1038/sj.bjc.6600643 |
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author | Ah-Weng, A Marsden, J R Sanders, D S A Waters, R |
author_facet | Ah-Weng, A Marsden, J R Sanders, D S A Waters, R |
author_sort | Ah-Weng, A |
collection | PubMed |
description | Dermatofibrosarcoma protuberans is an uncommon cutaneous tumour which rarely metastasises. However, local recurrence following apparently adequate surgical excision is well recognised, presumably as a result of sub-clinical contiguous growth, for which micrographically controlled excision would be a logical treatment. A retrospective study of all patients treated by micrographic surgery, from April 1995–March 2000, at a tertiary skin oncology centre. Twenty-one patients (11 males), age 14 to 71 years with dermatofibrosarcoma protuberans on the trunk (10 patients), groin (four), head and neck (four), and limbs (three) were treated. In 15 patients one micrographic layer cleared the tumour, and four were cleared with two layers. For one patient the second stage was completed by conventional excision guided by positive margins. Another patient with a multiply recurrent perineal dermatofibrosarcoma protuberans, not cleared in one area after two layers, died from a pulmonary embolus before total clearance could be achieved. There was no correlation between tumour size and lateral excision margin. No recurrence was observed during the follow-up, from 21 to 80 months, median 47 months. The study provides further support for micrographic surgery as the treatment of choice for dermatofibrosarcoma protuberans. British Journal of Cancer (2002) 87, 1386–1389. doi:10.1038/sj.bjc.6600643 www.bjcancer.com © 2002 Cancer Research UK |
format | Text |
id | pubmed-2376302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23763022009-09-10 Dermatofibrosarcoma protuberans treated by micrographic surgery Ah-Weng, A Marsden, J R Sanders, D S A Waters, R Br J Cancer Clinical Dermatofibrosarcoma protuberans is an uncommon cutaneous tumour which rarely metastasises. However, local recurrence following apparently adequate surgical excision is well recognised, presumably as a result of sub-clinical contiguous growth, for which micrographically controlled excision would be a logical treatment. A retrospective study of all patients treated by micrographic surgery, from April 1995–March 2000, at a tertiary skin oncology centre. Twenty-one patients (11 males), age 14 to 71 years with dermatofibrosarcoma protuberans on the trunk (10 patients), groin (four), head and neck (four), and limbs (three) were treated. In 15 patients one micrographic layer cleared the tumour, and four were cleared with two layers. For one patient the second stage was completed by conventional excision guided by positive margins. Another patient with a multiply recurrent perineal dermatofibrosarcoma protuberans, not cleared in one area after two layers, died from a pulmonary embolus before total clearance could be achieved. There was no correlation between tumour size and lateral excision margin. No recurrence was observed during the follow-up, from 21 to 80 months, median 47 months. The study provides further support for micrographic surgery as the treatment of choice for dermatofibrosarcoma protuberans. British Journal of Cancer (2002) 87, 1386–1389. doi:10.1038/sj.bjc.6600643 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-12-02 2002-11-26 /pmc/articles/PMC2376302/ /pubmed/12454766 http://dx.doi.org/10.1038/sj.bjc.6600643 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Ah-Weng, A Marsden, J R Sanders, D S A Waters, R Dermatofibrosarcoma protuberans treated by micrographic surgery |
title | Dermatofibrosarcoma protuberans treated by micrographic surgery |
title_full | Dermatofibrosarcoma protuberans treated by micrographic surgery |
title_fullStr | Dermatofibrosarcoma protuberans treated by micrographic surgery |
title_full_unstemmed | Dermatofibrosarcoma protuberans treated by micrographic surgery |
title_short | Dermatofibrosarcoma protuberans treated by micrographic surgery |
title_sort | dermatofibrosarcoma protuberans treated by micrographic surgery |
topic | Clinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376302/ https://www.ncbi.nlm.nih.gov/pubmed/12454766 http://dx.doi.org/10.1038/sj.bjc.6600643 |
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