Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

A case–control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=...

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Autores principales: Lee, K-M, Abel, J, Ko, Y, Harth, V, Park, W-Y, Seo, J-S, Yoo, K-Y, Choi, J-Y, Shin, A, Ahn, S-H, Noh, D-Y, Hirvonen, A, Kang, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376333/
https://www.ncbi.nlm.nih.gov/pubmed/12618873
http://dx.doi.org/10.1038/sj.bjc.6600761
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author Lee, K-M
Abel, J
Ko, Y
Harth, V
Park, W-Y
Seo, J-S
Yoo, K-Y
Choi, J-Y
Shin, A
Ahn, S-H
Noh, D-Y
Hirvonen, A
Kang, D
author_facet Lee, K-M
Abel, J
Ko, Y
Harth, V
Park, W-Y
Seo, J-S
Yoo, K-Y
Choi, J-Y
Shin, A
Ahn, S-H
Noh, D-Y
Hirvonen, A
Kang, D
author_sort Lee, K-M
collection PubMed
description A case–control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1–2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
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spelling pubmed-23763332009-09-10 Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women Lee, K-M Abel, J Ko, Y Harth, V Park, W-Y Seo, J-S Yoo, K-Y Choi, J-Y Shin, A Ahn, S-H Noh, D-Y Hirvonen, A Kang, D Br J Cancer Epidemiology A case–control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1–2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here. Nature Publishing Group 2003-03-10 2003-03-04 /pmc/articles/PMC2376333/ /pubmed/12618873 http://dx.doi.org/10.1038/sj.bjc.6600761 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Lee, K-M
Abel, J
Ko, Y
Harth, V
Park, W-Y
Seo, J-S
Yoo, K-Y
Choi, J-Y
Shin, A
Ahn, S-H
Noh, D-Y
Hirvonen, A
Kang, D
Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title_full Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title_fullStr Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title_full_unstemmed Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title_short Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
title_sort genetic polymorphisms of cytochrome p450 19 and 1b1, alcohol use, and breast cancer risk in korean women
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376333/
https://www.ncbi.nlm.nih.gov/pubmed/12618873
http://dx.doi.org/10.1038/sj.bjc.6600761
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