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Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression

Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Improved understanding of the mechanisms responsible for the differences between IBC and non-IBC might provide novel therapeutic targets. We studied 35 consecutive patients with IBC, biopsied prior to the initiation of ch...

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Autores principales: Colpaert, C G, Vermeulen, P B, Benoy, I, Soubry, A, Van Roy, F, van Beest, P, Goovaerts, G, Dirix, L Y, Van Dam, P, Fox, S B, Harris, A L, Van Marck, E A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376338/
https://www.ncbi.nlm.nih.gov/pubmed/12618881
http://dx.doi.org/10.1038/sj.bjc.6600807
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author Colpaert, C G
Vermeulen, P B
Benoy, I
Soubry, A
Van Roy, F
van Beest, P
Goovaerts, G
Dirix, L Y
Van Dam, P
Fox, S B
Harris, A L
Van Marck, E A
author_facet Colpaert, C G
Vermeulen, P B
Benoy, I
Soubry, A
Van Roy, F
van Beest, P
Goovaerts, G
Dirix, L Y
Van Dam, P
Fox, S B
Harris, A L
Van Marck, E A
author_sort Colpaert, C G
collection PubMed
description Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Improved understanding of the mechanisms responsible for the differences between IBC and non-IBC might provide novel therapeutic targets. We studied 35 consecutive patients with IBC, biopsied prior to the initiation of chemotherapy. Angiogenesis was evaluated by Chalkley counting and by assessment of endothelial cell proliferation (ECP) and vessel maturity. The presence of fibrin, expression of the hypoxia marker carbonic anhydrase IX (CA IX) and epithelialcadherin (E-cadherin) expression were immunohistochemically detected. The same parameters were obtained in a group of 104 non-IBC patients. Vascular density, assessed by Chalkley counting (P<0.0001), and ECP (P=0.01) were significantly higher in IBC than in non-IBC. Abundant stromal fibrin deposition was observed in 26% of IBC and in only 8% of non-IBC (P=0.02). Expression of CA IX was significantly less frequent in IBC than in non-IBC with early metastasis (P=0.047). There was a significant positive correlation between the expression of CA IX and ECP in IBC (r=0.4, P=0.03), implying that the angiogenesis is partly hypoxia driven. However, the higher ECP in IBC and the less frequent expression of CA IX in IBC vs non-IBC points at a role for other factors than hypoxia in stimulating angiogenesis. Strong, homogeneous E-cadherin expression was found at cell–cell contacts in all but two IBC cases, both in lymphovascular tumour emboli and in infiltrating tumour cells, challenging our current understanding of the metastatic process. Both the intense angiogenesis and the strong E-cadherin expression may contribute to the highly metastatic phenotype of IBC.
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spelling pubmed-23763382009-09-10 Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression Colpaert, C G Vermeulen, P B Benoy, I Soubry, A Van Roy, F van Beest, P Goovaerts, G Dirix, L Y Van Dam, P Fox, S B Harris, A L Van Marck, E A Br J Cancer Molecular and Cellular Pathology Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Improved understanding of the mechanisms responsible for the differences between IBC and non-IBC might provide novel therapeutic targets. We studied 35 consecutive patients with IBC, biopsied prior to the initiation of chemotherapy. Angiogenesis was evaluated by Chalkley counting and by assessment of endothelial cell proliferation (ECP) and vessel maturity. The presence of fibrin, expression of the hypoxia marker carbonic anhydrase IX (CA IX) and epithelialcadherin (E-cadherin) expression were immunohistochemically detected. The same parameters were obtained in a group of 104 non-IBC patients. Vascular density, assessed by Chalkley counting (P<0.0001), and ECP (P=0.01) were significantly higher in IBC than in non-IBC. Abundant stromal fibrin deposition was observed in 26% of IBC and in only 8% of non-IBC (P=0.02). Expression of CA IX was significantly less frequent in IBC than in non-IBC with early metastasis (P=0.047). There was a significant positive correlation between the expression of CA IX and ECP in IBC (r=0.4, P=0.03), implying that the angiogenesis is partly hypoxia driven. However, the higher ECP in IBC and the less frequent expression of CA IX in IBC vs non-IBC points at a role for other factors than hypoxia in stimulating angiogenesis. Strong, homogeneous E-cadherin expression was found at cell–cell contacts in all but two IBC cases, both in lymphovascular tumour emboli and in infiltrating tumour cells, challenging our current understanding of the metastatic process. Both the intense angiogenesis and the strong E-cadherin expression may contribute to the highly metastatic phenotype of IBC. Nature Publishing Group 2003-03-10 2003-03-04 /pmc/articles/PMC2376338/ /pubmed/12618881 http://dx.doi.org/10.1038/sj.bjc.6600807 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Colpaert, C G
Vermeulen, P B
Benoy, I
Soubry, A
Van Roy, F
van Beest, P
Goovaerts, G
Dirix, L Y
Van Dam, P
Fox, S B
Harris, A L
Van Marck, E A
Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title_full Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title_fullStr Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title_full_unstemmed Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title_short Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression
title_sort inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong e-cadherin expression
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376338/
https://www.ncbi.nlm.nih.gov/pubmed/12618881
http://dx.doi.org/10.1038/sj.bjc.6600807
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