Early detection of tumour immune-rejection using magnetic resonance imaging

Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other t...

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Autores principales: Hu, D-E, Beauregard, D A, Bearchell, M C, Thomsen, L L, Brindle, K M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376373/
https://www.ncbi.nlm.nih.gov/pubmed/12671716
http://dx.doi.org/10.1038/sj.bjc.6600814
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author Hu, D-E
Beauregard, D A
Bearchell, M C
Thomsen, L L
Brindle, K M
author_facet Hu, D-E
Beauregard, D A
Bearchell, M C
Thomsen, L L
Brindle, K M
author_sort Hu, D-E
collection PubMed
description Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem. Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.
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spelling pubmed-23763732009-09-10 Early detection of tumour immune-rejection using magnetic resonance imaging Hu, D-E Beauregard, D A Bearchell, M C Thomsen, L L Brindle, K M Br J Cancer Experimental Therapeutics Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem. Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume. Nature Publishing Group 2003-04-07 2003-04-01 /pmc/articles/PMC2376373/ /pubmed/12671716 http://dx.doi.org/10.1038/sj.bjc.6600814 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Hu, D-E
Beauregard, D A
Bearchell, M C
Thomsen, L L
Brindle, K M
Early detection of tumour immune-rejection using magnetic resonance imaging
title Early detection of tumour immune-rejection using magnetic resonance imaging
title_full Early detection of tumour immune-rejection using magnetic resonance imaging
title_fullStr Early detection of tumour immune-rejection using magnetic resonance imaging
title_full_unstemmed Early detection of tumour immune-rejection using magnetic resonance imaging
title_short Early detection of tumour immune-rejection using magnetic resonance imaging
title_sort early detection of tumour immune-rejection using magnetic resonance imaging
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376373/
https://www.ncbi.nlm.nih.gov/pubmed/12671716
http://dx.doi.org/10.1038/sj.bjc.6600814
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AT bearchellmc earlydetectionoftumourimmunerejectionusingmagneticresonanceimaging
AT thomsenll earlydetectionoftumourimmunerejectionusingmagneticresonanceimaging
AT brindlekm earlydetectionoftumourimmunerejectionusingmagneticresonanceimaging

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