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Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas

Earlier work describes a modest association between cholecystectomy and the risk of colorectal cancer. We conducted a prospective study of 85 184 women, 36–61 years old, who had no history of cancer to evaluate whether known risk factors for colorectal cancer, including dietary history, that have no...

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Autores principales: Schernhammer, E S, Leitzmann, M F, Michaud, D S, Speizer, F E, Giovannucci, E, Colditz, G A, Fuchs, C S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376770/
https://www.ncbi.nlm.nih.gov/pubmed/12556963
http://dx.doi.org/10.1038/sj.bjc.6600661
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author Schernhammer, E S
Leitzmann, M F
Michaud, D S
Speizer, F E
Giovannucci, E
Colditz, G A
Fuchs, C S
author_facet Schernhammer, E S
Leitzmann, M F
Michaud, D S
Speizer, F E
Giovannucci, E
Colditz, G A
Fuchs, C S
author_sort Schernhammer, E S
collection PubMed
description Earlier work describes a modest association between cholecystectomy and the risk of colorectal cancer. We conducted a prospective study of 85 184 women, 36–61 years old, who had no history of cancer to evaluate whether known risk factors for colorectal cancer, including dietary history, that have not been controlled for in previous analyses can help explain the observed association. During 16 years of follow-up, 877 cases of colorectal cancer were documented and 1452 women who underwent endoscopy during the follow-up time were diagnosed with distal adenomas. After adjustment for age and other known or suspected risk factors, we found a significant, positive association between cholecystectomy and the risk of colorectal cancer (multivariate relative risk RR 1.21, 95% CI 1.01–1.46). The risk was highest for cancers of the proximal colon (RR 1.34, 95% CI 0.97–1.88) and the rectum (RR 1.58, 95% CI 1.05–2.36). However, we did not observe a significant association between cholecystectomy and distal colorectal adenomas. In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors.
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spelling pubmed-23767702009-09-10 Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas Schernhammer, E S Leitzmann, M F Michaud, D S Speizer, F E Giovannucci, E Colditz, G A Fuchs, C S Br J Cancer Epidemiology Earlier work describes a modest association between cholecystectomy and the risk of colorectal cancer. We conducted a prospective study of 85 184 women, 36–61 years old, who had no history of cancer to evaluate whether known risk factors for colorectal cancer, including dietary history, that have not been controlled for in previous analyses can help explain the observed association. During 16 years of follow-up, 877 cases of colorectal cancer were documented and 1452 women who underwent endoscopy during the follow-up time were diagnosed with distal adenomas. After adjustment for age and other known or suspected risk factors, we found a significant, positive association between cholecystectomy and the risk of colorectal cancer (multivariate relative risk RR 1.21, 95% CI 1.01–1.46). The risk was highest for cancers of the proximal colon (RR 1.34, 95% CI 0.97–1.88) and the rectum (RR 1.58, 95% CI 1.05–2.36). However, we did not observe a significant association between cholecystectomy and distal colorectal adenomas. In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors. Nature Publishing Group 2003-01-13 2003-01-28 /pmc/articles/PMC2376770/ /pubmed/12556963 http://dx.doi.org/10.1038/sj.bjc.6600661 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Schernhammer, E S
Leitzmann, M F
Michaud, D S
Speizer, F E
Giovannucci, E
Colditz, G A
Fuchs, C S
Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title_full Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title_fullStr Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title_full_unstemmed Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title_short Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
title_sort cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376770/
https://www.ncbi.nlm.nih.gov/pubmed/12556963
http://dx.doi.org/10.1038/sj.bjc.6600661
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