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Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients
The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ receptors, respectively. The aim of this study was to evaluate the analgesic profile of the combination of morphine and oxycodone in cancer pain, compared to the standard administration of morphine alone. Cont...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376845/ https://www.ncbi.nlm.nih.gov/pubmed/14647133 http://dx.doi.org/10.1038/sj.bjc.6601365 |
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author | Lauretti, G R Oliveira, G M Pereira, N L |
author_facet | Lauretti, G R Oliveira, G M Pereira, N L |
author_sort | Lauretti, G R |
collection | PubMed |
description | The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ receptors, respectively. The aim of this study was to evaluate the analgesic profile of the combination of morphine and oxycodone in cancer pain, compared to the standard administration of morphine alone. Controlled-release formulations of oxycodone (CRO) and morphine (CRM) were compared in 26 patients. The study started with an open-label, randomised titration phase to achieve stable pain control for 7 days, followed by a double-blind, randomised crossover phase in two periods, 14 days each. At any point, patients were allowed to use oral immediate-release morphine (IRM) as needed, in order to keep visual analogue scale ⩽4. Pain, satisfaction, adverse effects and number of daily rescue morphine tablets were assessed. A total of 22 patients were evaluated. The weekly upload consumption ratio in morphine/oxycodone was 1 : 1.8 (1.80, 1.83, 1.76, 1.84). The weekly IRM consumption was higher in patients having CRM compared to patients having CRO (ratio morphine/oxycodone: 1.6, 1.6, 1.6, 1.7) (P<0.05). Patients receiving oxycodone complained of less nausea and vomiting. The rescue morphine analgesic consumption was 38% higher in patients receiving only morphine, compared to patients receiving both morphine and oxycodone. The results suggest that the combination of morphine/oxycodone (opioids with differential preferential sites of action) can be a useful alternative to morphine alone, resulting in a better analgesia profile and less emesis. |
format | Text |
id | pubmed-2376845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23768452009-09-10 Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients Lauretti, G R Oliveira, G M Pereira, N L Br J Cancer Clinical The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ receptors, respectively. The aim of this study was to evaluate the analgesic profile of the combination of morphine and oxycodone in cancer pain, compared to the standard administration of morphine alone. Controlled-release formulations of oxycodone (CRO) and morphine (CRM) were compared in 26 patients. The study started with an open-label, randomised titration phase to achieve stable pain control for 7 days, followed by a double-blind, randomised crossover phase in two periods, 14 days each. At any point, patients were allowed to use oral immediate-release morphine (IRM) as needed, in order to keep visual analogue scale ⩽4. Pain, satisfaction, adverse effects and number of daily rescue morphine tablets were assessed. A total of 22 patients were evaluated. The weekly upload consumption ratio in morphine/oxycodone was 1 : 1.8 (1.80, 1.83, 1.76, 1.84). The weekly IRM consumption was higher in patients having CRM compared to patients having CRO (ratio morphine/oxycodone: 1.6, 1.6, 1.6, 1.7) (P<0.05). Patients receiving oxycodone complained of less nausea and vomiting. The rescue morphine analgesic consumption was 38% higher in patients receiving only morphine, compared to patients receiving both morphine and oxycodone. The results suggest that the combination of morphine/oxycodone (opioids with differential preferential sites of action) can be a useful alternative to morphine alone, resulting in a better analgesia profile and less emesis. Nature Publishing Group 2003-12-01 2003-11-25 /pmc/articles/PMC2376845/ /pubmed/14647133 http://dx.doi.org/10.1038/sj.bjc.6601365 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Lauretti, G R Oliveira, G M Pereira, N L Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title | Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title_full | Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title_fullStr | Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title_full_unstemmed | Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title_short | Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
title_sort | comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients |
topic | Clinical |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376845/ https://www.ncbi.nlm.nih.gov/pubmed/14647133 http://dx.doi.org/10.1038/sj.bjc.6601365 |
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