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Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine

In order to evaluate the diagnostic reliability of the thyroid cancers listed in adult registries from the Ukraine and Belarus, a histological review was organised of 327 randomly selected thyroid carcinoma cases diagnosed between 1980 and 1999. A final diagnosis was reached at a 5-day consensus con...

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Autores principales: Franc, B, Valenty, M, Galakhin, K, Kovalchuk, E, Kulagenko, V, Puchkou, A, Sidorov, Y, Tirmarche, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376855/
https://www.ncbi.nlm.nih.gov/pubmed/14647144
http://dx.doi.org/10.1038/sj.bjc.6601395
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author Franc, B
Valenty, M
Galakhin, K
Kovalchuk, E
Kulagenko, V
Puchkou, A
Sidorov, Y
Tirmarche, M
author_facet Franc, B
Valenty, M
Galakhin, K
Kovalchuk, E
Kulagenko, V
Puchkou, A
Sidorov, Y
Tirmarche, M
author_sort Franc, B
collection PubMed
description In order to evaluate the diagnostic reliability of the thyroid cancers listed in adult registries from the Ukraine and Belarus, a histological review was organised of 327 randomly selected thyroid carcinoma cases diagnosed between 1980 and 1999. A final diagnosis was reached at a 5-day consensus conference by six pathologists who met around a multiheaded microscope. The study concluded with a comparison between the final diagnosis and the initial diagnosis. The pathologists agreed with the initial diagnosis of malignancy in 286 cases (88%). A final diagnosis of papillary, follicular or medullary thyroid carcinoma was reached in 86, 4, and 6% of the cases respectively. In 2.8% of the cases reviewed, diagnostic discrepancies persisted. The percentage of agreement between the final diagnosis and the initial diagnosis was 93%, with a weighted κ-statistic of 0.61 (confidence interval 95% (CI(95%)): [0.45–0.77]). In all, 89% of the 286 confirmed cancer cases were in agreement for the type of cancer, with a κ-statistic of 0.56 (CI(95%): [0.43–0.69]). The level of agreement differed according to cancer categories, with concordance rates of 94, 40 and 33% for papillary, follicular and medullary thyroid carcinomas respectively. The low prevalence of follicular thyroid carcinomas in the adult population studied calls for further exploration. The discrepancies and classification difficulties encountered were analysed.
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spelling pubmed-23768552009-09-10 Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine Franc, B Valenty, M Galakhin, K Kovalchuk, E Kulagenko, V Puchkou, A Sidorov, Y Tirmarche, M Br J Cancer Molecular and Cellular Pathology In order to evaluate the diagnostic reliability of the thyroid cancers listed in adult registries from the Ukraine and Belarus, a histological review was organised of 327 randomly selected thyroid carcinoma cases diagnosed between 1980 and 1999. A final diagnosis was reached at a 5-day consensus conference by six pathologists who met around a multiheaded microscope. The study concluded with a comparison between the final diagnosis and the initial diagnosis. The pathologists agreed with the initial diagnosis of malignancy in 286 cases (88%). A final diagnosis of papillary, follicular or medullary thyroid carcinoma was reached in 86, 4, and 6% of the cases respectively. In 2.8% of the cases reviewed, diagnostic discrepancies persisted. The percentage of agreement between the final diagnosis and the initial diagnosis was 93%, with a weighted κ-statistic of 0.61 (confidence interval 95% (CI(95%)): [0.45–0.77]). In all, 89% of the 286 confirmed cancer cases were in agreement for the type of cancer, with a κ-statistic of 0.56 (CI(95%): [0.43–0.69]). The level of agreement differed according to cancer categories, with concordance rates of 94, 40 and 33% for papillary, follicular and medullary thyroid carcinomas respectively. The low prevalence of follicular thyroid carcinomas in the adult population studied calls for further exploration. The discrepancies and classification difficulties encountered were analysed. Nature Publishing Group 2003-12-01 2003-11-25 /pmc/articles/PMC2376855/ /pubmed/14647144 http://dx.doi.org/10.1038/sj.bjc.6601395 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular and Cellular Pathology
Franc, B
Valenty, M
Galakhin, K
Kovalchuk, E
Kulagenko, V
Puchkou, A
Sidorov, Y
Tirmarche, M
Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title_full Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title_fullStr Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title_full_unstemmed Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title_short Histological validation of diagnoses of thyroid cancer among adults in the registries of Belarus and the Ukraine
title_sort histological validation of diagnoses of thyroid cancer among adults in the registries of belarus and the ukraine
topic Molecular and Cellular Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376855/
https://www.ncbi.nlm.nih.gov/pubmed/14647144
http://dx.doi.org/10.1038/sj.bjc.6601395
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