Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour

Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage indu...

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Autores principales: Driessens, G, Harsan, L, Robaye, B, Waroquier, D, Browaeys, P, Giannakopoulos, X, Velu, T, Bruyns, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376913/
https://www.ncbi.nlm.nih.gov/pubmed/12915886
http://dx.doi.org/10.1038/sj.bjc.6601163
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author Driessens, G
Harsan, L
Robaye, B
Waroquier, D
Browaeys, P
Giannakopoulos, X
Velu, T
Bruyns, C
author_facet Driessens, G
Harsan, L
Robaye, B
Waroquier, D
Browaeys, P
Giannakopoulos, X
Velu, T
Bruyns, C
author_sort Driessens, G
collection PubMed
description Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour.
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spelling pubmed-23769132009-09-10 Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour Driessens, G Harsan, L Robaye, B Waroquier, D Browaeys, P Giannakopoulos, X Velu, T Bruyns, C Br J Cancer Experimental Therapeutics Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour. Nature Publishing Group 2003-08-18 2003-08-12 /pmc/articles/PMC2376913/ /pubmed/12915886 http://dx.doi.org/10.1038/sj.bjc.6601163 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Experimental Therapeutics
Driessens, G
Harsan, L
Robaye, B
Waroquier, D
Browaeys, P
Giannakopoulos, X
Velu, T
Bruyns, C
Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title_full Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title_fullStr Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title_full_unstemmed Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title_short Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
title_sort micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376913/
https://www.ncbi.nlm.nih.gov/pubmed/12915886
http://dx.doi.org/10.1038/sj.bjc.6601163
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