Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports

Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receivi...

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Autores principales: Brickell, K, Porter, D, Thompson, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376914/
https://www.ncbi.nlm.nih.gov/pubmed/12915866
http://dx.doi.org/10.1038/sj.bjc.6601137
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author Brickell, K
Porter, D
Thompson, P
author_facet Brickell, K
Porter, D
Thompson, P
author_sort Brickell, K
collection PubMed
description Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receiving phenytoin will be prescribed treatment with fluoropyrimidines. We present two cases of clinical phenytoin toxicity occurring after starting treatment with 5-fluorouracil/folinic acid (5FU/FA) and a third who developed clinical phenytoin toxicity after starting capecitabine (an orally administered prodrug of fluorouracil).
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spelling pubmed-23769142009-09-10 Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports Brickell, K Porter, D Thompson, P Br J Cancer Clinical Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. As more people with significant medical comorbidities are now being considered for chemotherapy, it is increasingly likely that people receiving phenytoin will be prescribed treatment with fluoropyrimidines. We present two cases of clinical phenytoin toxicity occurring after starting treatment with 5-fluorouracil/folinic acid (5FU/FA) and a third who developed clinical phenytoin toxicity after starting capecitabine (an orally administered prodrug of fluorouracil). Nature Publishing Group 2003-08-18 2003-08-12 /pmc/articles/PMC2376914/ /pubmed/12915866 http://dx.doi.org/10.1038/sj.bjc.6601137 Text en Copyright © 2003 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical
Brickell, K
Porter, D
Thompson, P
Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title_full Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title_fullStr Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title_full_unstemmed Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title_short Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
title_sort phenytoin toxicity due to fluoropyrimidines (5fu/capecitabine): three case reports
topic Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376914/
https://www.ncbi.nlm.nih.gov/pubmed/12915866
http://dx.doi.org/10.1038/sj.bjc.6601137
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AT thompsonp phenytointoxicityduetofluoropyrimidines5fucapecitabinethreecasereports

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