A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors

Tumour angiogenesis is initiated by angiogenic factors that are produced in large amounts by hypoxic tumour cells. The inhibition of this step may lead to tumour-specific antiangiogenesis because normal tissues are not usually hypoxic. On the other hand, blocking a biological function of endothelial...

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Detalles Bibliográficos
Autores principales: Shimamura, M, Nagasawa, H, Ashino, H, Yamamoto, Y, Hazato, T, Uto, Y, Hori, H, Inayama, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377039/
https://www.ncbi.nlm.nih.gov/pubmed/12610518
http://dx.doi.org/10.1038/sj.bjc.6600667

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