Endothelin-1: a multifunctional molecule in cancer

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for e...

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Detalles Bibliográficos
Autores principales: Grant, K, Loizidou, M, Taylor, I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377061/
https://www.ncbi.nlm.nih.gov/pubmed/12610497
http://dx.doi.org/10.1038/sj.bjc.6700750
Descripción
Sumario:Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.

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